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anti-CD8 antibody :: Mouse anti-Cat (Cat) CD8 Monoclonal Antibody

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Catalog # MBS532699
Unit / Price
  0.5 mg  /  $625 +1 FREE 8GB USB
anti-CD8 antibody
Product Name

CD8, Monoclonal Antibody

Also Known As

CD8 antibody (FITC)

Product Synonym Names
Monoclonal CD8; Anti-CD8; CD-8; CD8; CD 8
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
192
OMIM
186730
3D Structure
ModBase 3D Structure for P10966
Clonality
Monoclonal
Isotype
IgG1
Clone Number
FCD8
Host
Mouse
Species Reactivity
Cat (Cat)
Form/Format
Supplied as a liquid in PBS, with NaN3 added as preservative.
Concentration
0.5 mg/ml (lot specific)
Biological Significance
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Tag/Conjugate
FITC
Immunogen
CD8 antibody (FITC) was raised in mouse using feline CD8 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-CD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD8 antibody
Mouse monoclonal CD8 antibody (FITC)
Applications Tested/Suitable for anti-CD8 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CD8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,237 Da
NCBI Official Full Name
CD8 antigen, partial
NCBI Official Synonym Full Names
CD8b molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
LY3; P37; LEU2; LYT3; CD8B1
  [Similar Products]
NCBI Protein Information
T-cell surface glycoprotein CD8 beta chain
UniProt Protein Name
T-cell surface glycoprotein CD8 beta chain
UniProt Synonym Protein Names
CD_antigen: CD8b
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CD8B1  [Similar Products]
UniProt Entry Name
CD8B_HUMAN
NCBI Summary for CD8
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
UniProt Comments for CD8
CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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