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anti-TYR antibody :: Mouse Tyrosinase Monoclonal Antibody

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Catalog # MBS245263
Unit / Price
  0.125 mL  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

Tyrosinase, Monoclonal Antibody

Also Known As

Mouse Monoclonal (IgG2a) to Human Tyrosinase

Product Synonym Names
Anti-Tyrosinase Antibody IHC-plus; TYR; CMM8; LB24-AB; SHEP3; SK29-AB; Monophenol monooxygenase; Tumor rejection antigen AB; OCA1A; Tyrosinase; OCAIA; Human Tyrosinase
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
529
OMIM
gene 606952
3D Structure
ModBase 3D Structure for P14679
Clonality
Monoclonal
Isotype
IgG2a
Host
Mouse
Species Reactivity
Cat, Dog, Human
Specificity
Recognizes a cluster of proteins between 70-80kD, identified as human tyrosinase. Occasionally a minor band at 55kD is also detected. Does not cross-react with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Species cross-reactivity: canine and feline. Weak cross-reactivity with mouse.
Purity/Purification
Protein A Purified
Form/Format
PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
Concentration
0.2 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Recombinant tyrosinase protein. Epitope: 1-433.
Immunogen Type
Recombinant protein
Immunogen
Tyrosinase antibody was raised against recombinant tyrosinase protein. Epitope: 1-433.
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-TYR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TYR antibody
Tyrosinase is a copper containing oxidase that catalyzes the first step in the conversion of tyrosine to melanin, and other polyphenolic compounds. It also catalyzes the rate-limiting conversion of tyrosine to DOPA. Mutations in tyrosinase are the cause of oculocutaneous albinism 1A.
Applications Tested/Suitable for anti-TYR antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TYR antibody
ELISA, ICC, IF, IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TYR antibody
Anti-Tyrosinase antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TYR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TYR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,914 Da
NCBI Official Full Name
tyrosinase
NCBI Official Synonym Full Names
tyrosinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
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NCBI Protein Information
tyrosinase; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB
UniProt Protein Name
Tyrosinase
UniProt Synonym Protein Names
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB
Protein Family
UniProt Gene Name
UniProt Entry Name
TYRO_HUMAN
NCBI Summary for TYR
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for TYR
TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - riboflavin; Amino Acid Metabolism - tyrosine; EC 1.14.18.1; Oxidoreductase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: lysosome; perinuclear region of cytoplasm; cytoplasm; melanosome membrane; melanosome; integral to membrane; Golgi-associated vesicle

Molecular Function: protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; monophenol monooxygenase activity

Biological Process: cell proliferation; visual perception; thymus development; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process

Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ib; Albinism, Oculocutaneous, Type Ia; Skin/hair/eye Pigmentation, Variation In, 3
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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