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anti-TPSAB1 antibody :: Mouse TPSAB1 / Mast Cell Tryptase Monoclonal Antibody

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Catalog # MBS245244
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

TPSAB1 / Mast Cell Tryptase, Monoclonal Antibody

Popular Item
Also Known As

Mouse Monoclonal [clone AA1] (IgG1) to Human TPSAB1 / Mast Cell Tryptase

Product Synonym Names
Anti-TPSAB1 / Mast Cell Tryptase Antibody (clone AA1) IHC-plus; TPSAB1; Alpha tryptase; Mast cell alpha II tryptase; Tryptase alpha-1; Tryptase beta I; Tryptase-III; TPSB1; Tryptase alpha II; TPS1; TPS2; Tryptase beta-1; Tryptase-1; Tryptase-I; Mast cell beta I tryptase; Tryptase alpha/beta 1; Human TPSAB1; Mast Cell Tryptase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
275
OMIM
191080
3D Structure
ModBase 3D Structure for Q15661
Clonality
Monoclonal
Isotype
IgG1
Clone Number
AA1
Host
Mouse
Species Reactivity
Cat, Dog, Human, Monkey, Rat
Specificity
Recognizes human mast cell tryptase, both alpha and beta isoforms. Is an excellent marker for mast cells, and does not bind to any other cell type in immunohistology.
Purity/Purification
Protein G Purified
Form/Format
PBS, pH 7.4, 0.09% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Human mast cell tryptase purified from human lung tissue.
Immunogen Type
Purified protein
Immunogen
TPSAB1 / Mast Cell Tryptase antibody was raised against human mast cell tryptase purified from human lung tissue.
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing. Store undiluted.
Other Notes
Small volumes of anti-TPSAB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TPSAB1 antibody
Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TPSAB1 antibody
ELISA, IHC-Fr, IHC-P (2.5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TPSAB1 antibody
Anti-TPSAB1 / Mast Cell Tryptase antibody IHC of human breast, mast cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TPSAB1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TPSAB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,533 Da
NCBI Official Full Name
tryptase alpha/beta-1
NCBI Official Synonym Full Names
tryptase alpha/beta 1
NCBI Official Symbol
TPSAB1  [Similar Products]
NCBI Official Synonym Symbols
TPS1; TPS2; TPSB1
  [Similar Products]
NCBI Protein Information
tryptase alpha/beta-1; tryptase I; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; mast cell beta I tryptase; mast cell alpha II tryptase
UniProt Protein Name
Tryptase alpha/beta-1
UniProt Synonym Protein Names
Tryptase I; Tryptase alpha-1
Protein Family
UniProt Gene Name
TPSAB1  [Similar Products]
UniProt Synonym Gene Names
TPS1; TPS2; TPSB1; Tryptase-1  [Similar Products]
UniProt Entry Name
TRYB1_HUMAN
NCBI Summary for TPSAB1
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
UniProt Comments for TPSAB1
TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.21.59; Secreted; Protease

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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