NP_006592.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
prostaglandin E synthase 3 isoform a
NCBI Official Synonym Full Names
prostaglandin E synthase 3 (cytosolic)
NCBI Protein Information
prostaglandin E synthase 3; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; unactive progesterone receptor, 23 kD
UniProt Protein Name
Prostaglandin E synthase 3
UniProt Synonym Protein Names
Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23
UniProt Synonym Gene Names
UniProt Entry Name
TEBP_HUMAN
UniProt Comments for PTGES3
TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.
Protein type: Transferase; Nuclear receptor co-regulator; EC 5.3.99.3; Chaperone; Isomerase
Chromosomal Location of Human Ortholog: 12q13.3|12
Cellular Component: nucleoplasm; chromosome, telomeric region; telomerase holoenzyme complex; cytoplasm; cytosol; nucleus
Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity
Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; signal transduction; prostaglandin biosynthetic process; telomere maintenance
Product References and Citations for anti-PTGES3 antibody
1. Johnson J.L., Beito T. G., Krco C.J. & Toft D.O. (1994) Mol Cell Biol 14: 1956-63. 2. Weikl T., Abelmann K. & Buchner J. (1999) J Mol Biol 293: 685-91. 3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A. & Toft, D.O. (2000) J Biol Chem 275: 23045-52. 4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237- 50. 5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70. 6. Holt S.E., et al. (1999) Genes Dev 13: 817-26. 7. Hu J., Toft D., Anselmo D. & Wang X. (2002) J Virol 76: 269-79. 8. Felts, S.J. & Toft D.O. (2003) Cell Stress Chaperones 8: 108-13. 9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia. 1. Shimamura, T. et al. (2012). Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumour Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer. Clin Cancer Res. 18, 4973-4985. doi: 10.1158/1078-0432.CCR-11-2967
Research Articles on PTGES3
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Products associated with anti-PTGES3 antibody
Pathways associated with anti-PTGES3 antibody
Diseases associated with anti-PTGES3 antibody
Organs/Tissues associated with anti-PTGES3 antibody
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