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anti-CD8a antibody :: Mouse anti-Chicken CD8a CD8a Monoclonal Antibody

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Catalog # MBS531997
Unit / Price
  0.5 mg  /  $430 +1 FREE 8GB USB
anti-CD8a antibody
Product Name

CD8a, Monoclonal Antibody

Full Product Name

CD8a antibody

Product Synonym Names
Monoclonal CD8a; Anti-CD8a; Ly2; CD-8a; CD 8a; CD8a
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
186910
3D Structure
ModBase 3D Structure for P01732
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
3-298
Host
Mouse
Species Reactivity
Chicken CD8a
Form/Format
Supplied as a liquid in 100mM BBS, pH 8.2.
Concentration
0.5 mg/ml (lot specific)
Biological Significance
CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules.
Immunogen
CD8a antibody was raised in Mouse using the alpha chainc of chicken CD8 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-CD8a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD8a antibody
Mouse monoclonal CD8a antibody
Product Categories/Family for anti-CD8a antibody
Applications Tested/Suitable for anti-CD8a antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for CD8a. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,214 Da
NCBI Official Full Name
CD8a molecule
NCBI Official Synonym Full Names
CD8a molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
CD8; MAL; p32; Leu2
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NCBI Protein Information
T-cell surface glycoprotein CD8 alpha chain
UniProt Protein Name
T-cell surface glycoprotein CD8 alpha chain
UniProt Synonym Protein Names
T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CD8A_HUMAN
NCBI Summary for CD8a
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for CD8a
CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; MHC class I protein binding; coreceptor activity; protein kinase binding

Biological Process: antigen processing and presentation; regulation of immune response; T cell activation; T cell mediated immunity; positive regulation of calcium-mediated signaling; cytotoxic T cell differentiation; immune response; defense response to virus; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Cd8 Deficiency, Familial
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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