NP_001184110.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tubulin beta-3 chain isoform 2
NCBI Official Synonym Full Names
tubulin beta 3 class III
NCBI Official Synonym Symbols
CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A [Similar Products]
NCBI Protein Information
tubulin beta-3 chain
UniProt Protein Name
Tubulin beta-3 chain
UniProt Synonym Protein Names
Tubulin beta-4 chain; Tubulin beta-III
UniProt Synonym Gene Names
NCBI Summary for TUBB3
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
UniProt Comments for TUBB3
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Product References and Citations for anti-TUBB3 antibody
Deng H, Xu H, Zhang X, Sun Y, Wang R, Brann D, Yang F; Journal: Toxicol Appl Pharmacol. Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-beta1/ROCK1 pathway in silicosis in rat. Yingying X, Caijuan W, Yenan Y, Yuqin T, Xueqin C, Zhongming W; Journal: Med Sci Monit.
Research Articles on TUBB3
Precautions
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Disclaimer
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Pathways associated with anti-TUBB3 antibody
Diseases associated with anti-TUBB3 antibody
Disease Name |
Pubmed Publications |
Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement Antibodies |
>514 publications with TUBB3 and Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement |
Neoplasms Antibodies |
>47 publications with TUBB3 and Neoplasms |
Nervous System Diseases Antibodies |
>16 publications with TUBB3 and Nervous System Diseases |
Ovarian Neoplasms Antibodies |
>12 publications with TUBB3 and Ovarian Neoplasms |
Breast Neoplasms Antibodies |
>9 publications with TUBB3 and Breast Neoplasms |
Fibrosis Antibodies |
>8 publications with TUBB3 and Fibrosis |
Neoplasms, Experimental Antibodies |
>5 publications with TUBB3 and Neoplasms, Experimental |
Brain Diseases Antibodies |
>4 publications with TUBB3 and Brain Diseases |
Carcinoma, Squamous Cell Antibodies |
>4 publications with TUBB3 and Carcinoma, Squamous Cell |
Eye Diseases Antibodies |
>4 publications with TUBB3 and Eye Diseases |
Organs/Tissues associated with anti-TUBB3 antibody
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