NP_001001522.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transgelin
NCBI Official Synonym Full Names
transgelin
NCBI Protein Information
transgelin
UniProt Protein Name
Transgelin
UniProt Synonym Protein Names
22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha; SM22-alpha
UniProt Synonym Gene Names
UniProt Entry Name
TAGL_HUMAN
NCBI Summary for TAGLN
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TAGLN
TAGLN: Actin cross-linking/gelling protein. Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. Belongs to the calponin family.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 11q23.2
Molecular Function: protein binding
Biological Process: epithelial cell differentiation; muscle development
Product References and Citations for anti-TAGLN antibody
Shapland, C., et al. 1993. Purification and properties of transgelin: a transformation and shape change sensitive Actin-gelling protein. J. Cell Biol. 121: 1065-1073
Research Articles on TAGLN
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Diseases associated with anti-TAGLN antibody
Organs/Tissues associated with anti-TAGLN antibody
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