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anti-HLA B7 antibody :: Mouse HLA B7 Monoclonal Antibody

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Catalog # MBS213215
Unit / Price
  0.2 mg  /  $455 +1 FREE 8GB USB
Product Name

HLA B7, Monoclonal Antibody

Popular Item
Also Known As

MOUSE ANTI HUMAN HLA B7

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
362
OMIM
142830
3D Structure
ModBase 3D Structure for P01889
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BB7.1
Host
Mouse
Species Reactivity
Cynomolgus monkey
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Preparation
Immunogen
Papain solubilized HLA-B7 antigen
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-HLA B7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HLA B7 antibody
Mouse anti Human HLA B7 antibody, clone BB7.1 recognizes the HLA B7 antigen and does not cross-react with HLA B27 or other related antigens. It can be used to distinguish true HLA B27 positives from false HLA B27 positives (i.e. HLA B7 positive) in the investigation of diseases such as ankylosing spondylitis and anterior uveitis. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In humans, this complex is referred to as the human leukocyte antigen (HLA) region. There are 3 major MHC class I proteins encoded by the HLA which are HLA A, HLA B and HLA C. The HLA B gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene.
Applications Tested/Suitable for anti-HLA B7 antibody
Flow cytometry (FC/FACS)
Application Notes for anti-HLA B7 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1 x 106 cells or 100ul whole blood.
Flow Cytometry: Maximum Dilution: 1/50

Testing Data of anti-HLA B7 antibody
Staining of human peripheral blood lymphocytes with Mouse anti Human HLA-B7:FITC (MBS211127)
anti-HLA B7 antibody Testing Data image
Testing Data of anti-HLA B7 antibody
Staining of human peripheal blood lymphocytes from an HLA-B7 positive donor with Mouse anti Human HLA-B7
anti-HLA B7 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for HLA B7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,460 Da
NCBI Official Full Name
major histocompatibility complex, class I, B
NCBI Official Synonym Full Names
major histocompatibility complex, class I, B
NCBI Official Symbol
HLA-B  [Similar Products]
NCBI Official Synonym Symbols
AS; HLAB; SPDA1
  [Similar Products]
NCBI Protein Information
major histocompatibility complex, class I, B; HLA class I histocompatibility antigen, B alpha chain; MHC Class I HLA heavy chain; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen GN00104; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; leukocyte antigen class I-B; lymphocyte antigen
UniProt Protein Name
HLA class I histocompatibility antigen, B-7 alpha chain
UniProt Synonym Protein Names
MHC class I antigen B*7
UniProt Gene Name
HLA-B  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
1B07_HUMAN
NCBI Summary for HLA B7
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA B7
HLAB iso7: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; endoplasmic reticulum; early endosome membrane; integral to plasma membrane; plasma membrane; integral to membrane; MHC class I protein complex

Molecular Function: peptide antigen binding; chaperone binding; TAP binding; receptor binding

Biological Process: regulation of immune response; viral reproduction; detection of bacterium; regulation of interleukin-12 production; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response; protection from natural killer cell mediated cytotoxicity; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; regulation of T cell anergy; regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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