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anti-TTF-1 antibody :: Mouse anti-Human, Dog TTF-1 Monoclonal Antibody

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Catalog # MBS370112
Unit / Price
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  5 Control Slides  /  $130 +1 FREE 8GB USB
  3 ml (Prediluted)  /  $170 +1 FREE 8GB USB
  7 mL (Prediluted)  /  $190 +1 FREE 8GB USB
  0.1 mL (Concentrate)  /  $195 +1 FREE 8GB USB
  15 mL (Prediluted)  /  $285 +1 FREE 8GB USB
  0.5 mL (Concentrate)  /  $315 +1 FREE 8GB USB
  1 mL (Concentrate)  /  $530 +1 FREE 8GB USB
Product Name

TTF-1, Monoclonal Antibody

Full Product Name

TTF-1

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (36985602..36989430, complement). Location: 14q13
OMIM
118700
3D Structure
ModBase 3D Structure for Q7KZF6
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8G7G3/1
Host
Mouse
Species Reactivity
Human, Dog
Form/Format
TTF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Adenocarcinoma of Lung, Normal Lung, Thyroid
Localization
Nuclear
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-TTF-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TTF-1 antibody
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific to the thyroid, lung and diencephalon. It is also known as thyroid-specific enhancer binding protein and NKX-2. It is used as a marker to determine if a tumor oringinates in the lung or thyroid. TTF-1 positive cells are found in Type II pneumocytes and Clara cells in the lung. In the thyroid, follicular and parafollicular cells are positive. TTF-1 is useful in differentiating primary Adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. It can also be used to differentiate Small- Cell Lung Carcinoma from lymphoid infiltrates. For lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. Small-Cell Carcinomas (of any primary site) are usually positive.

Dilution Information of anti-TTF-1 antibody
anti-TTF-1 antibody Dilution Information image
Immunohistochemistry (IHC) of anti-TTF-1 antibody
anti-TTF-1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TTF-1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41606 Da
NCBI Official Full Name
homeobox protein Nkx-2.1 isoform 1
NCBI Official Synonym Full Names
NK2 homeobox 1
NCBI Official Symbol
NKX2-1  [Similar Products]
NCBI Official Synonym Symbols
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; TITF1; TTF-1; NKX2.1
  [Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.1; NK-2 homolog A; OTTHUMP00000178847; OTTHUMP00000225297; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A
UniProt Protein Name
Homeobox protein Nkx-2.1
UniProt Synonym Protein Names
Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1
UniProt Gene Name
NKX2-1  [Similar Products]
UniProt Synonym Gene Names
NKX2A; TITF1; TTF1  [Similar Products]
UniProt Entry Name
NKX21_HUMAN
NCBI Summary for TTF-1
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq]
UniProt Comments for TTF-1
Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.

Subunit structure: Interacts with WWTR1. Ref.10

Subcellular location: Nucleus.

Tissue specificity: Thyroid and lung.

Post-translational modification: Phosphorylated on serine residues

Involvement in disease: Defects in NKX2-1 are the cause of benign hereditary chorea (BHC) [

MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. Ref.11 Ref.15Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [

MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems. Ref.12 Ref.13 Ref.14 Ref.15

Sequence similarities: Belongs to the NK-2 homeobox family.Contains 1 homeobox DNA-binding domain.

Sequence caution: The sequence AAH06221.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA23527.1 differs from that shown. Reason: Erroneous gene model prediction.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-TTF-1 antibody
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