P28906.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35 kDa , 40 kDa
NCBI Official Full Name
Hematopoietic progenitor cell antigen CD34
NCBI Official Synonym Full Names
CD34 molecule
NCBI Protein Information
hematopoietic progenitor cell antigen CD34
UniProt Protein Name
Hematopoietic progenitor cell antigen CD34
UniProt Synonym Protein Names
CD_antigen: CD34
NCBI Summary for CD34
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for CD34
CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: apical plasma membrane; basal plasma membrane; cytoplasm; external side of plasma membrane; integral to plasma membrane; intercellular bridge; lysosome; perinuclear region of cytoplasm; plasma membrane
Molecular Function: carbohydrate binding; transcription factor binding
Biological Process: cell motility involved in cell locomotion; cell proliferation; cell-cell adhesion; cell-matrix adhesion; endothelial cell proliferation; glomerular filtration; hemopoiesis; leukocyte migration; negative regulation of blood coagulation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of interleukin-10 production; positive regulation of odontogenesis; regulation of blood pressure; regulation of immune response; signal transduction; tissue homeostasis
Research Articles on CD34
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Products associated with anti-CD34 antibody
Pathways associated with anti-CD34 antibody
Diseases associated with anti-CD34 antibody
Organs/Tissues associated with anti-CD34 antibody
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