AAH64936.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,205 Da
NCBI Official Full Name
ARCN1 protein
NCBI Official Synonym Full Names
archain 1
NCBI Official Synonym Symbols
NCBI Protein Information
coatomer subunit delta
UniProt Protein Name
Coatomer subunit delta
UniProt Synonym Protein Names
Archain; Delta-coat protein; Delta-COP
UniProt Synonym Gene Names
UniProt Entry Name
COPD_HUMAN
NCBI Summary for ARCN1
This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]
UniProt Comments for ARCN1
ARCN1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: Golgi apparatus; clathrin adaptor complex; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; cytoplasm; COPI vesicle coat; cytosol
Biological Process: cerebellar Purkinje cell layer maturation; intracellular protein transport; COPI coating of Golgi vesicle; pigmentation; adult locomotory behavior; retrograde vesicle-mediated transport, Golgi to ER
Research Articles on ARCN1
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Pathways associated with anti-ARCN1 antibody
Diseases associated with anti-ARCN1 antibody
Organs/Tissues associated with anti-ARCN1 antibody
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