NP_061357.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
G protein-coupled receptor kinase 5
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 5
NCBI Official Synonym Symbols
NCBI Protein Information
G protein-coupled receptor kinase 5; g protein-coupled receptor kinase GRK5
UniProt Protein Name
G protein-coupled receptor kinase 5
UniProt Synonym Protein Names
G protein-coupled receptor kinase GRK5
UniProt Synonym Gene Names
UniProt Entry Name
GRK5_MOUSE
UniProt Comments for Grk5
GRK5: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G- protein-coupled receptor, LRP6 during Wnt signaling (in vitro). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.16; AGC group; GRK family; GRK subfamily
Cellular Component: nucleoplasm; nuclear membrane; focal adhesion; membrane; cytoplasm; plasma membrane; nucleus
Molecular Function: transferase activity; G-protein coupled receptor kinase activity; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; lipid binding; ATP binding; protein kinase activity
Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; tachykinin signaling pathway; Wnt receptor signaling pathway; apoptosis; protein amino acid autophosphorylation; signal transduction; phosphorylation; protein amino acid phosphorylation; regulation of G-protein coupled receptor protein signaling pathway; negative regulation of apoptosis
Research Articles on Grk5
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Pathways associated with anti-Grk5 antibody
Diseases associated with anti-Grk5 antibody
Organs/Tissues associated with anti-Grk5 antibody
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