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anti-TNFAIP3 antibody :: Mouse anti-Human A-20/TNFAIP3 Monoclonal Antibody

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Catalog # MBS668220
Unit / Price
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  0.1 mg  /  $290 +1 FREE 8GB USB
Product Name

A-20/TNFAIP3, Monoclonal Antibody

Popular Item
Full Product Name

A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)

Product Synonym Names
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21580
IgG1, Kappa
Clone Number
Species Reactivity
Protein G choromatography
25 ug in 50 uL/ 100 ug in 200 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody.
PBS containing 0.05% BSA and 0.05% sodium azide.
Target Modification
Produced from Ascites
Preparation and Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Other Notes
Small volumes of anti-TNFAIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNFAIP3 antibody
Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)
Applications Tested/Suitable for anti-TNFAIP3 antibody
Application Notes for anti-TNFAIP3 antibody
Western Blot: 4-6 ug/mL

Western Blot (WB) of anti-TNFAIP3 antibody
Expression analysis of A20. Anti-A20 antibody (Clone: ABM1G20) was tested at 4 ug/ml on THP-1 Lysate.
anti-TNFAIP3 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC) of anti-TNFAIP3 antibody
Cell surface FLOW analysis of A20 (Clone : ABM1G20) on HepG2 cells using 0.5 ug/10^6 cells of antibody. Goat anti-mouse PE conjugate was used as secondary antibody. Green represents isotope control , red represents anti-A20 antibody
anti-TNFAIP3 antibody Flow Cytometry (FC) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for TNFAIP3. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor necrosis factor alpha-induced protein 3
NCBI Official Synonym Full Names
TNF alpha induced protein 3
NCBI Official Symbol
TNFAIP3  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
tumor necrosis factor alpha-induced protein 3
UniProt Protein Name
Tumor necrosis factor alpha-induced protein 3
UniProt Synonym Protein Names
OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20
UniProt Gene Name
TNFAIP3  [Similar Products]
UniProt Synonym Gene Names
OTUD7C; TNF alpha-induced protein 3  [Similar Products]
UniProt Entry Name
NCBI Summary for TNFAIP3
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for TNFAIP3
TNFAIP3: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax. By TNF. Belongs to the peptidase C64 family.

Protein type: Apoptosis; Protease; EC; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; lysosome; nucleus

Molecular Function: DNA binding; kinase binding; ligase activity; protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding

Biological Process: apoptosis; B-1 B cell homeostasis; inflammatory response; inhibition of NF-kappaB transcription factor; negative regulation of B cell activation; negative regulation of bone resorption; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein kinase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of protein catabolic process; protein deubiquitination; protein oligomerization; regulation of defense response to virus by host; regulation of germinal center formation; regulation of inflammatory response; response to molecule of bacterial origin; response to muramyl dipeptide
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