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anti-ADAMTS1 antibody :: Mouse anti-Human A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) Monoclonal Antibody

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Catalog # MBS2012517 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $145 +1 FREE 8GB USB
  0.1 mg  /  $175 +1 FREE 8GB USB
  0.2 mg  /  $230 +1 FREE 8GB USB
  1 mg  /  $515 +1 FREE 8GB USB
Western Blot (WB)
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1), Monoclonal Antibody

Popular Item
Full Product Name

Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S-DLPGT SYDANRQCQF TFGEDSKHCP DAASTCSTLW CTGTSGGVLV CQTKHFPWAD GTSCGEGKWC INGKCVNKTD RKHFDTPFHG SWGMWGPWGD CSRTCGGGVQ YTMRECDNPV PKNGGKYCEG KRVRYRSCNL EDCP
OMIM
AF170084 mRNA
3D Structure
ModBase 3D Structure for Q9UHI8
Clonality
Monoclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Specificity
The antibody is a mouse monoclonal antibody raised against ADAMTS1. It has been selected for its ability to recognize ADAMTS1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
500ug/ml (lot specific)
Immunogen
Recombinant ADAMTS1 (Asp476~Pro614) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2061332
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ADAMTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAMTS1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-ADAMTS1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-ADAMTS1 antibody
Western Blot: Sample: Recombinant ADAMTS1, Human.
anti-ADAMTS1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105,358 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 1
NCBI Official Symbol
ADAMTS1  [Similar Products]
NCBI Official Synonym Symbols
C3-C5; METH1
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Synonym Protein Names
METH-1
UniProt Gene Name
ADAMTS1  [Similar Products]
UniProt Synonym Gene Names
KIAA1346; METH1; ADAM-TS 1; ADAM-TS1; ADAMTS-1  [Similar Products]
NCBI Summary for ADAMTS1
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS1
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: basement membrane; cytoplasmic vesicle; cytosol

Molecular Function: heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding

Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ADAMTS1 antibody
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