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anti-ADAMTS4 antibody :: anti-Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Monoclonal Antibody

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Catalog # MBS2012823 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.2 mg  /  $260 +1 FREE 8GB USB
anti-ADAMTS4 antibody
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4), Monoclonal Antibody

Popular Item
Also Known As

FITC-linked Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
837
Chromosome Location
Chromosome: 1; NC_000001.10 (161159538..161168845, complement). Location: 1q21-q23
OMIM
603876
3D Structure
ModBase 3D Structure for O75173
Clonality
Monoclonal
Species Reactivity
Human
Concentration
500ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-ADAMTS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ADAMTS4 antibody
Applications Tested/Suitable for anti-ADAMTS4 antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,197 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 4
NCBI Official Symbol
ADAMTS4  [Similar Products]
NCBI Official Synonym Symbols
ADMP-1; ADAMTS-2; ADAMTS-4
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Synonym Protein Names
ADMP-1; Aggrecanase-1
UniProt Gene Name
ADAMTS4  [Similar Products]
UniProt Synonym Gene Names
KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4  [Similar Products]
UniProt Entry Name
ATS4_HUMAN
NCBI Summary for ADAMTS4
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS4
ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Secreted, signal peptide; Protease; Motility/polarity/chemotaxis; Secreted; EC 3.4.24.82

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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