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anti-NR5A2 antibody :: Mouse anti-Human a-Fetoprotein Receptor Monoclonal Antibody

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Catalog # MBS602928
Unit / Price
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  0.2 mg  /  $480 +1 FREE 8GB USB
anti-NR5A2 antibody
Product Name

a-Fetoprotein Receptor (NR5A2), Monoclonal Antibody

Popular Item
Full Product Name

a-Fetoprotein Receptor (AFPr)

Product Synonym Names
Anti -a-Fetoprotein Receptor (AFPr)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (199996730..200146552). Location: 1q32.1
3D Structure
ModBase 3D Structure for O00482
Clone Number
Species Reactivity
Recognizes different determinants of human alpha-fetoprotein receptor. Blocks alpha-fetoprotein and it's receptor.
Affinity Purified
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Purified, full-length, native human alpha fetoprotein receptor
Positive Control
Ovarian adenocarcinoma SKOV3, human mammary carcinoma MCF-7, human cervical carcinoma Hela, B-cell lymphoma Raji and T-cell lymphoma Jurkat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-NR5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR5A2 antibody
AFP's cell growth-regulatory effects are mediated by its specific plasma membrane receptors coupled with its transmembrane signaling transduction through the pathway of cAMP-PKA and intracellular calcium to regulate the expression of oncogenes. The properties of the AFP receptor as well as the subsequent events after AFP binding are still undefined.
Product Categories/Family for anti-NR5A2 antibody
Applications Tested/Suitable for anti-NR5A2 antibody
Immunocytochemistry (ICC)
Application Notes for anti-NR5A2 antibody
Suitable for use in Immunocytochemistry and Blocking studies.
NCBI/Uniprot data below describe general gene information for NR5A2. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,331 Da[Similar Products]
NCBI Official Full Name
alpha1-fetoprotein transcription factor
NCBI Official Synonym Full Names
nuclear receptor subfamily 5, group A, member 2
NCBI Official Symbol
NR5A2  [Similar Products]
NCBI Official Synonym Symbols
B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta
  [Similar Products]
NCBI Protein Information
nuclear receptor subfamily 5 group A member 2; nuclear receptor NR5A2; liver receptor homolog 1; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
UniProt Protein Name
Nuclear receptor subfamily 5 group A member 2
UniProt Synonym Protein Names
Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1
UniProt Gene Name
NR5A2  [Similar Products]
UniProt Synonym Gene Names
B1F; CPF; FTF; hB1F; LRH-1  [Similar Products]
UniProt Entry Name
UniProt Comments for NR5A2
NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; phospholipid binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of viral genome replication; intracellular receptor-mediated signaling pathway; bile acid metabolic process; positive regulation of transcription, DNA-dependent; endocrine pancreas development; regulation of cell proliferation; cholesterol homeostasis; embryonic development; regulation of transcription, DNA-dependent; homeostatic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
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