Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-A-RAF antibody :: Rabbit anti-Human A-RAF Monoclonal Antibody Catalog # MBS179793 Unit / Price 0.1 mg / $340 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name A-RAF, Monoclonal Antibody Full Product Name Anti-A-RAF Rabbit Monoclonal Antibody Product Synonym Names Serine/threonine-protein kinase A-Raf; 2.7.11.1; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks; ARAF; ARAF1; PKS; PKS2 Product Gene Name anti-A-RAF antibody[Similar Products] Product Synonym Gene Name ARAF[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM X04790 mRNA 3D Structure ModBase 3D Structure for P10398 Clonality Monoclonal Host Rabbit Species Reactivity Human Purity/Purification Affinity-chromatography Form/Format Liquid Immunogen A synthesized peptide derived from human A-RAF Tissue Specificity Predominantly in urogenital tissues. Contents Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Preparation and Storage Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. ISO Certification Manufactured in an ISO 9001:2008 Certified Laboratory. Other Notes Small volumes of anti-A-RAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-A-RAF antibody Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Applications Tested/Suitable for anti-A-RAF antibody Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) Application Notes for anti-A-RAF antibody WB: 1:500-1:2000IHC: 1:50-1:200ICC/IF: 1:50-1:200FC/FACS: 1:50 Western Blot (WB) of anti-A-RAF antibody Western blot analysis of A-RAF expression in A375 cell lysate (MBS179793).Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-ARAF monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for ARAF TOP NCBI/Uniprot data below describe general gene information for A-RAF. It may not necessarily be applicable to this product. NCBI GI # 371875793 NCBI GeneID 369 NCBI Accession # NP_001243125.1 [Other Products] NCBI GenBank Nucleotide # NM_001256196.1 [Other Products] UniProt Primary Accession # P10398 [Other Products] UniProt Secondary Accession # P07557; Q5H9B2; Q5H9B3[Other Products] UniProt Related Accession # P10398[Other Products] Molecular Weight 67585 MW TOP NCBI Official Full Name serine/threonine-protein kinase A-Raf isoform 2 NCBI Official Synonym Full Names A-Raf proto-oncogene, serine/threonine kinase NCBI Official Symbol ARAF [Similar Products] NCBI Official Synonym Symbols PKS2; A-RAF; ARAF1; RAFA1 [Similar Products] NCBI Protein Information serine/threonine-protein kinase A-Raf UniProt Protein Name Serine/threonine-protein kinase A-Raf UniProt Synonym Protein Names Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks UniProt Gene Name ARAF [Similar Products] UniProt Synonym Gene Names ARAF1; PKS; PKS2 [Similar Products] TOP NCBI Summary for A-RAF This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012] TOP UniProt Comments for A-RAF Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Research Articles on A-RAF 1. The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2, thus rendering cells susceptible to apoptosis TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated withanti-A-RAF antibody Reference Product PubMed Publications HRAS antibody >3 publications with A-RAF and HRAS PIK3R1 antibody >1 publications with A-RAF and PIK3R1 Pathways associated with anti-A-RAF antibody Products by Pathway Pathway Diagram Acute Myeloid Leukemia Pathway antibodies Acute Myeloid Leukemia Pathway Diagram Acute Myeloid Leukemia Pathway antibodies Acute Myeloid Leukemia Pathway Diagram Alcoholism Pathway antibodies Alcoholism Pathway Diagram Alcoholism Pathway antibodies Alcoholism Pathway Diagram Bladder Cancer Pathway antibodies Bladder Cancer Pathway Diagram Bladder Cancer Pathway antibodies Bladder Cancer Pathway Diagram Chronic Myeloid Leukemia Pathway antibodies Chronic Myeloid Leukemia Pathway Diagram Chronic Myeloid Leukemia Pathway antibodies Chronic Myeloid Leukemia Pathway Diagram Colorectal Cancer Pathway antibodies Colorectal Cancer Pathway Diagram Colorectal Cancer Pathway antibodies Colorectal Cancer Pathway Diagram Diseases associated with anti-A-RAF antibody Disease Name Pubmed Publications Neoplasms Antibodies >11 publications with A-RAF and Neoplasms Necrosis Antibodies >5 publications with A-RAF and Necrosis Inflammation Antibodies >3 publications with A-RAF and Inflammation Fibrosis Antibodies >2 publications with A-RAF and Fibrosis Drug Toxicity Antibodies >2 publications with A-RAF and Drug Toxicity Adenocarcinoma Antibodies >2 publications with A-RAF and Adenocarcinoma Weight Loss Antibodies >2 publications with A-RAF and Weight Loss Lung Diseases Antibodies >1 publications with A-RAF and Lung Diseases Heart Diseases Antibodies >1 publications with A-RAF and Heart Diseases Hypertension Antibodies >1 publications with A-RAF and Hypertension Organs/Tissues associated with anti-A-RAF antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >14 publications with A-RAF and Blood Vascular Antibodies >5 publications with A-RAF and Vascular Spleen Antibodies >4 publications with A-RAF and Spleen Thyroid Antibodies >3 publications with A-RAF and Thyroid Bone Antibodies >3 publications with A-RAF and Bone Eye Antibodies >3 publications with A-RAF and Eye Kidney Antibodies >2 publications with A-RAF and Kidney Lung Antibodies >2 publications with A-RAF and Lung Mouth Antibodies >2 publications with A-RAF and Mouth Skin Antibodies >2 publications with A-RAF and Skin TOP © 2006-18 MyBioSource.com. 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