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anti-Activin R2A antibody :: Mouse anti-Human Activin R2A Monoclonal Antibody

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Catalog # MBS690639
Unit / Price
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  0.1 mg  /  $490 +1 FREE 8GB USB
Immunohistochemistry
Product Name

Activin R2A, Monoclonal Antibody

Popular Item
Full Product Name

Mouse Anti-Human Activin R2A

Product Synonym Names
Anti human Activin R-2A (#6J16)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.12 (147844517..147930827). Location: 2q22.3
OMIM
102581
3D Structure
ModBase 3D Structure for P27037
Clonality
Monoclonal
Isotype
IgG2
Clone Number
(6J16)
Host
Mouse
Species Reactivity
Human
Specificity
This antibody was selected for its ability to detect human Activin RIIA. No cross reactivity was found to hActivin RI and RIIB.
Purity/Purification
Protein G affinity chromatography
Form/Format
Lyophilized
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human Activin receptor IIA extra cellular domain. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Protein RefSeq
NP_001607.1
mRNA RefSeq
NM_001616.3
Antigen
recombinant human Activin receptor IIA extracellular domain
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-Activin R2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Activin R2A antibody
Activin proteins are involved in a wide range of biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of reproductive physiology, inflammation, and carcinogenesis. They function through heteromeric complexes of type I and type II serine/threonine kinase receptors. Dimeric ligands bind to a type II receptor, such as Activin Receptor IIA (ActRIIA or activin R2A), which then associates with a type I receptor to initiate signal transduction. ActRIIA mediates the pleiotropic effects of Activins and Inhibins as well as several members of the BMP and GDF families of TGF beta like proteins. Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa) extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aa cytoplasmic region that includes the kinase domain and a PDZbinding motif. Within the ECD, human ActRIIA shares 98% aa sequence identity with mouse and rat ActRIIA. Signaling through ActRIIA is modulated by its interaction with RGMB/ DRAGON, Cripto, Endoglin/CD105, TGFbeta RIII/Betaglycan, or BAMBI. These interactions can enhance ligandinduced signaling or interfere with signaling by preventing ActRIIA association with type I receptors. Activininduced responses can also be limited by the enhanced internalization of ActRIIA following its association with the cytoplasmic proteins ARIP1 and ARIP2.
Applications Tested/Suitable for anti-Activin R2A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Activin R2A antibody
WB: 1:500 – 1:1000
IHC (Paraffin): 1:50 – 1:100

Immunohistochemistry of anti-Activin R2A antibody
Human placenta (formalin fixed and paraffin embedded) section is subjected to IHC
anti-Activin R2A antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for Activin R2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,848 Da
NCBI Official Full Name
activin receptor type-2A isoform 1
NCBI Official Synonym Full Names
activin A receptor, type IIA
NCBI Official Symbol
ACVR2A  [Similar Products]
NCBI Official Synonym Symbols
ACVR2; ACTRII
  [Similar Products]
NCBI Protein Information
activin receptor type-2A
UniProt Protein Name
Activin receptor type-2A
UniProt Synonym Protein Names
Activin receptor type IIA
UniProt Gene Name
ACVR2A  [Similar Products]
UniProt Synonym Gene Names
ACVR2; ACTR-IIA; ACTRIIA  [Similar Products]
UniProt Entry Name
AVR2A_HUMAN
NCBI Summary for Activin R2A
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
UniProt Comments for Activin R2A
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor: Magnesium or manganese

By similarity.

Subunit structure: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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