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anti-ACVR2B antibody :: Mouse anti-Human Activin Receptor Type IIB Monoclonal Antibody

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Catalog # MBS605715
Unit / Price
  0.1 mg  /  $645 +1 FREE 8GB USB
  0.5 mg  /  $1,320 +1 FREE 8GB USB
anti-ACVR2B antibody
Product Name

Activin Receptor Type IIB (ACVR2B), Monoclonal Antibody

Also Known As

Activin Receptor Type IIB (RIIB)

Product Synonym Names
Anti -Activin Receptor Type IIB (RIIB)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3; NC_000003.11 (38495790..38534633). Location: 3p22
OMIM
602730
3D Structure
ModBase 3D Structure for Q13705
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9H21
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes recombinant human Activin RIIB. Shows ~5% crossreactivity with recombinant human Activin RIIA.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
Immunogen
Recombinant protein corresponding to the extracellular domain of human Activin RIIB, expressed in NSO cells.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ACVR2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACVR2B antibody
Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, BMP-7, GDF-1, GDF-3, Myostatin (GDF-8), and GDF-11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.
Applications Tested/Suitable for anti-ACVR2B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ACVR2B antibody
Suitable for use in Direct ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1.0ug/ml. The detection limit for recombinant human Activin RIIB is ~2ng/well.
Western Blot: 1-2ug/ml. The detection limit for recombinant human Activin RIIB is ~20ng/lane under reducing and non-reducing conditions.
NCBI/Uniprot data below describe general gene information for ACVR2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,724 Da[Similar Products]
NCBI Official Full Name
activin receptor type IIB
NCBI Official Synonym Full Names
activin A receptor, type IIB
NCBI Official Symbol
ACVR2B  [Similar Products]
NCBI Official Synonym Symbols
HTX4; ACTRIIB; ActR-IIB; MGC116908
  [Similar Products]
NCBI Protein Information
activin receptor type-2B; OTTHUMP00000161965
UniProt Protein Name
Activin receptor type-2B
UniProt Synonym Protein Names
Activin receptor type IIB
Protein Family
UniProt Gene Name
ACVR2B  [Similar Products]
UniProt Entry Name
AVR2B_HUMAN
NCBI Summary for ACVR2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]
UniProt Comments for ACVR2B
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Membrane protein, integral; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; metal ion binding; growth factor binding; activin binding; protein serine/threonine/tyrosine kinase activity; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; pancreas development; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development

Disease: Heterotaxy, Visceral, 4, Autosomal
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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