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anti-ADARB1 antibody :: Mouse anti-Human Adenosine Deaminase, RNA-specific, B1 Monoclonal Antibody

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Catalog # MBS607515
Unit / Price
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  0.05 mg  /  $365 +1 FREE 8GB USB
anti-ADARB1 antibody
Product Name

Adenosine Deaminase, RNA-specific, B1 (ADARB1), Monoclonal Antibody

Full Product Name

Adenosine Deaminase, RNA-specific, B1 (ADARB1, ADAR2, Double-stranded RNA-specific Editase 1, DRABA2, DRADA2, dsRNA Adenosine Deaminase, RNA Editase, RNA-editing Deaminase 1, RED1, RNA-editing Enzyme 1)

Product Synonym Names
Anti -Adenosine Deaminase, RNA-specific, B1 (ADARB1, ADAR2, Double-stranded RNA-specific Editase 1, DRABA2, DRADA2, dsRNA Adenosine Deaminase, RNA Editase, RNA-editing Deaminase 1, RED1, RNA-editing Enzyme 1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 21; NC_000021.8 (46494493..46646478). Location: 21q22.3
3D Structure
ModBase 3D Structure for O43263
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9j17
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human ADARB1.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Immunogen
Partial recombinant sequence from the N-terminus of human ADARB1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADARB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADARB1 antibody
The mammalian Adenosine Deaminases Acting on RNA (ADAR) constitute a family of sequence-related proteins involved in pre-mRNA editing of nuclear transcripts through site-speci c adenosine modi cation. ADARs are not active on adenosine-mononucleotide and are only distantly related by sequence to adenosine and AMP deaminases involved in purine metabolism. The ADARs convert certain adenosine bases in an RNA transcript into inosines by removing an amino group involved in Watson-Crick base pairing. The ADARs recognize a double stranded RNA (dsRNA) structure in the transcript that is formed between the editing site complementary sequence (ECS), usually located in the downstream 3' intron of the transcript, and the sequence to be edited. The ADAR family of proteins consists of ADAR1 and ADAR2 which are expressed in many tissues and ADAR3 which is expressed in the brain. Regulated levels of ADAR1 expression are critical for embryonic erythropoiesis in the liver. Results show a requirement of regulated increase in the ADAR1 expression in liver at E12 and E13 stages. Failure to increase ADAR1 expression may result in underediting of the RNA of currently unknown target genes, which in turn affects proliferation and/or differentiation of erythrocytes. The absence of mature erythrocytes would lead to tissue hypoxia and the eventual death of the embryo. The best characterized target transcripts that undergo RNA editing by ADARs encode glutamate-sensitive ion channels that are expressed by neurons of the central nervous system.
Product Categories/Family for anti-ADARB1 antibody
Applications Tested/Suitable for anti-ADARB1 antibody
Western Blot (WB), Gel Shift Assay (GS/EMSA)
Application Notes for anti-ADARB1 antibody
Suitable for use in Western Blot and Dot Blot.
NCBI/Uniprot data below describe general gene information for ADARB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
75,970 Da[Similar Products]
NCBI Official Full Name
adenosine deaminase, RNA-specific, B1 (RED1 homolog rat), isoform CRA_e
NCBI Official Synonym Full Names
adenosine deaminase, RNA-specific, B1
NCBI Official Symbol
ADARB1  [Similar Products]
NCBI Official Synonym Symbols
RED1; ADAR2; DRABA2; DRADA2
  [Similar Products]
NCBI Protein Information
double-stranded RNA-specific editase 1; RNA editase; RED1 homolog; OTTHUMP00000115339; OTTHUMP00000115340; OTTHUMP00000115341; OTTHUMP00000115342; OTTHUMP00000174981; OTTHUMP00000214128; RNA-editing enzyme 1; RNA editing deaminase 1; RNA-editing deaminase 1; dsRNA adenosine deaminase; human dsRNA adenosine deaminase DRADA2; adenosine deaminase, RNA-specific, B1 (RED1 homolog rat); adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)
UniProt Protein Name
RNA editing deaminase 1
UniProt Gene Name
hRED1  [Similar Products]
UniProt Entry Name
O43263_HUMAN
NCBI Summary for ADARB1
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq]
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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