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anti-ALDH10 antibody :: anti-Human Aldehyde dehydrogenase 10 Monoclonal Antibody

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Catalog # MBS475132
Unit / Price
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  0.1 mL  /  $335 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Aldehyde dehydrogenase 10 (ALDH10), Monoclonal Antibody

Popular Item
Full Product Name

Anti-Aldehyde dehydrogenase 10 Mouse mAb

Product Synonym Names
Aldehyde dehydrogenase; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase 3 family member A2; ALDH10; ALDH3A2; DKFZp686E23276; FALDH; Fatty aldehyde dehydrogenase; FLJ20851; Microsomal aldehyde dehydrogenase; OTTHUMP00000065799; OTTHUMP00000065800; OTTHUMP00000065801; SLS
Product Synonym Gene Name
aldh3a2; SLS; FALDH[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L47162 mRNA
3D Structure
ModBase 3D Structure for P51648
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
3F7-H9-E12
Host
Mouse
Source: Human
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
Concentration
1mg/ml (lot specific)
Immunogen
Purified recombinant human Aldehyde dehydrogenase 10 protein fragments expressed in E Coli.
Sensitivity
This antibody detects endogenous levels of Aldehyde dehydrogenase 10 and does not cross-react with related proteins.
Sequence Similarities
Belongs to the aldehyde dehydrogenase family.
Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Other Notes
Small volumes of anti-ALDH10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALDH10 antibody
Entrez Summary: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene
UniPort Summary Function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.
Applications Tested/Suitable for anti-ALDH10 antibody
Western Blot (WB)
Application Notes for anti-ALDH10 antibody
WB: 1:1000

Western Blot (WB) of anti-ALDH10 antibody
Western blot detection of Aldehyde dehydrogenase 10 in A549, U251 and HepG2 cell lysates using Aldehyde dehydrogenase 10 mouse mAb (1:1000 diluted).Predicted band size:55KDa.Observed band size:55KDa.
anti-ALDH10 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ALDH10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55
NCBI Official Full Name
fatty aldehyde dehydrogenase isoform 2
NCBI Official Synonym Full Names
aldehyde dehydrogenase 3 family member A2
NCBI Official Symbol
ALDH3A2  [Similar Products]
NCBI Official Synonym Symbols
SLS; FALDH; ALDH10
  [Similar Products]
NCBI Protein Information
fatty aldehyde dehydrogenase
UniProt Protein Name
Fatty aldehyde dehydrogenase
UniProt Synonym Protein Names
Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase
UniProt Gene Name
ALDH3A2  [Similar Products]
UniProt Synonym Gene Names
ALDH10; FALDH  [Similar Products]
NCBI Summary for ALDH10
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ALDH10
ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Membrane protein, integral; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; peroxisomal membrane

Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; long-chain-alcohol oxidase activity

Biological Process: aldehyde metabolic process; central nervous system development; epidermis development; fatty acid alpha-oxidation; peripheral nervous system development; phytol metabolic process; sphingolipid biosynthetic process

Disease: Sjogren-larsson Syndrome
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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