NP_004295.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma receptor tyrosine kinase
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Entry Name
ALK_HUMAN
NCBI Summary for ALK, CD246
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK, CD246
ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors
Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; Alk family
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: integral to plasma membrane; intracellular; protein complex
Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cell proliferation; neuron development; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; regulation of apoptosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Neuroblastoma, Susceptibility To, 3
Research Articles on ALK, CD246
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Products associated with anti-ALK, CD246 antibody
Pathways associated with anti-ALK, CD246 antibody
Diseases associated with anti-ALK, CD246 antibody
Disease Name |
Pubmed Publications |
Lung Diseases Antibodies |
>1335 publications with ALK, CD246 and Lung Diseases |
Lung Neoplasms Antibodies |
>1326 publications with ALK, CD246 and Lung Neoplasms |
Lymphoma, Large-Cell, Anaplastic Antibodies |
>1218 publications with ALK, CD246 and Lymphoma, Large-Cell, Anaplastic |
Carcinoma, Non-Small-Cell Lung Antibodies |
>874 publications with ALK, CD246 and Carcinoma, Non-Small-Cell Lung |
Chromosome Aberrations Antibodies |
>369 publications with ALK, CD246 and Chromosome Aberrations |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>359 publications with ALK, CD246 and Lymphoma, Large B-Cell, Diffuse |
Neuroblastoma Antibodies |
>229 publications with ALK, CD246 and Neuroblastoma |
Adenocarcinoma of lung Antibodies |
>168 publications with ALK, CD246 and Adenocarcinoma of lung |
Inflammation Antibodies |
>137 publications with ALK, CD246 and Inflammation |
Cell Transformation, Neoplastic Antibodies |
>130 publications with ALK, CD246 and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-ALK, CD246 antibody
Organ/Tissue Name |
Pubmed Publications |
Blood Antibodies |
>785 publications with ALK, CD246 and Blood |
Brain Antibodies |
>315 publications with ALK, CD246 and Brain |
Muscle Antibodies |
>301 publications with ALK, CD246 and Muscle |
Liver Antibodies |
>251 publications with ALK, CD246 and Liver |
Connective Tissue Antibodies |
>46 publications with ALK, CD246 and Connective Tissue |
Spleen Antibodies |
>41 publications with ALK, CD246 and Spleen |
Stomach Antibodies |
>33 publications with ALK, CD246 and Stomach |
Testis Antibodies |
>23 publications with ALK, CD246 and Testis |
Trachea Antibodies |
>5 publications with ALK, CD246 and Trachea |
Uncharacterized Tissue Antibodies |
>1 publications with ALK, CD246 and Uncharacterized Tissue |
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