• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ALK, CD246 antibody :: Mouse ALK, CD246 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS766542
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $265 +1 FREE 8GB USB
Product Name

ALK, CD246, Monoclonal Antibody

Popular Item
Full Product Name

ALK, CD246 Mouse Monoclonal

Product Synonym Names
ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS766542 Technical Datasheet
OMIM
105590
Clonality
Monoclonal
Isotype
IgG2a
Host
Mouse
Species Reactivity
Human; other species are not tested.
Specificity
Please decide specifity by homology.
Purity/Purification
>=95% as determined by SDS-PAGE
Protein A+G purification
Form/Format
Liquid
PBS with 0.02% Sodium azide and 50% Glycerol pH 7.3
Immunogen
Anaplastic lymphoma receptor tyrosine kinase
Calculated MW
176 kDa
Preparation and Storage
Store at -20°C for 24 months (Avoid repeated freeze/ thaw cycles)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ALK, CD246 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALK, CD246 antibody
ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35)translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). TheEML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).
Applications Tested/Suitable for anti-ALK, CD246 antibody
ELISA, IHC, WB
Application Notes for anti-ALK, CD246 antibody
WB 1:500-1:5000
IHC 1:20-1:200

Immunohistochemistry IHC of anti-ALK, CD246 antibody
Immunohistochemistry of paraffin-embedded human lymphoma slide using MBS766542 (ALK, CD246 Antibody)at dilution of 1:50
anti-ALK, CD246 antibody Immunohistochemistry IHC (IHC) image
Testing Data TD of anti-ALK, CD246 antibody
Recombinant protein were subjected to SDS PAGE followed by Western BLot with MBS766542 (ALK, CD246 Antibody) at dilution of 1:1000
anti-ALK, CD246 antibody Testing Data TD image
NCBI/Uniprot data below describe general gene information for ALK, CD246. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ALK tyrosine kinase receptor
NCBI Official Synonym Full Names
anaplastic lymphoma receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
CD246; NBLST3
  [Similar Products]
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
UniProt Gene Name
UniProt Entry Name
ALK_HUMAN
NCBI Summary for ALK, CD246
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK, CD246
ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors

Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; Alk family

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: integral to plasma membrane; intracellular; protein complex

Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cell proliferation; neuron development; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; regulation of apoptosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Neuroblastoma, Susceptibility To, 3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000