NP_000336
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein alpha
NCBI Protein Information
alpha-synuclein
UniProt Protein Name
Alpha-synuclein
UniProt Synonym Protein Names
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
UniProt Synonym Gene Names
NCBI Summary for SNCA
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
UniProt Comments for SNCA
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Product References and Citations for anti-SNCA antibody
Jakes, R., et al. (1994) FEBS lett. 345:27-32; Ueda, K., et al. (1993) Proc. Natl.Acad. Sci. USA 90:11282-11286; Kim, J. (1997) Molecules and Cells 7:78-83; Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344:325-334.
Research Articles on SNCA
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Products associated with anti-SNCA antibody
Pathways associated with anti-SNCA antibody
Diseases associated with anti-SNCA antibody
Organs/Tissues associated with anti-SNCA antibody
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