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anti-AMACRacemase antibody :: Rabbit anti-Human AMACRacemase Monoclonal Antibody

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Catalog # MBS370005
Unit / Price
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  5 Control Slides  /  $130 +1 FREE 8GB USB
  3 ml (Prediluted)  /  $225 +1 FREE 8GB USB
  0.1 mL (Concentrate)  /  $230 +1 FREE 8GB USB
  7 mL (Prediluted)  /  $330 +1 FREE 8GB USB
  0.5 mL (Concentrate)  /  $435 +1 FREE 8GB USB
  15 mL (Prediluted)  /  $560 +1 FREE 8GB USB
  1 mL (Concentrate)  /  $630 +1 FREE 8GB USB
Product Name

AMACRacemase, Monoclonal Antibody

Full Product Name

AMACRacemase RMab

Product Synonym Names
AMACRacemase RMab
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (33987091..34008220, complement). Location: 5p13
OMIM
214950
3D Structure
ModBase 3D Structure for Q9UHK6
Clonality
Monoclonal
Isotype
IgG
Clone Number
13H4
Host
Rabbit
Species Reactivity
Human
Form/Format
P504S/AMACR is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Prostatic Adenocarcinoma
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-AMACRacemase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AMACRacemase antibody
AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker.High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34betaE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.

Dilution Information of anti-AMACRacemase antibody
anti-AMACRacemase antibody Dilution Information image
Immunohistochemistry (IHC) of anti-AMACRacemase antibody
anti-AMACRacemase antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AMACRacemase. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,387 Da
NCBI Official Full Name
Alpha-methylacyl-CoA racemase
NCBI Official Synonym Full Names
alpha-methylacyl-CoA racemase
NCBI Official Symbol
AMACR  [Similar Products]
NCBI Official Synonym Symbols
RM; RACE; CBAS4
  [Similar Products]
NCBI Protein Information
alpha-methylacyl-CoA racemase; OTTHUMP00000115916; OTTHUMP00000115917; OTTHUMP00000219978; OTTHUMP00000219979; OTTHUMP00000219980; 2-methylacyl-CoA racemase
UniProt Protein Name
Alpha-methylacyl-CoA racemase
UniProt Synonym Protein Names
2-methylacyl-CoA racemase
UniProt Gene Name
AMACR  [Similar Products]
UniProt Entry Name
AMACR_HUMAN
NCBI Summary for AMACRacemase
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq]
UniProt Comments for AMACRacemase
Function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

Catalytic activity: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.

Pathway: Lipid metabolism; bile acid biosynthesis.Lipid metabolism; fatty acid metabolism.

Subcellular location: Peroxisome. Mitochondrion Ref.1.

Involvement in disease: Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [

MIM:604489]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy. Ref.2Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [

MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile. Ref.2 Ref.11

Sequence similarities: Belongs to the CaiB/BaiF CoA-transferase family.

Sequence caution: The sequence ACL67853.1 differs from that shown. Reason: Aberrant splicing.The sequence ACL67854.1 differs from that shown. Reason: Aberrant splicing.The sequence CAB44062.1 differs from that shown. Reason: Frameshift at positions 62, 65 and 114.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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