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anti-ACY1 antibody :: Rat anti-Human Aminoacylase 1 Monoclonal Antibody

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Catalog # MBS606305
Unit / Price
  0.1 mg  /  $630 +1 FREE 8GB USB
anti-ACY1 antibody
Product Name

Aminoacylase 1 (ACY1), Monoclonal Antibody

Also Known As

Aminoacylase 1 (ACY1)

Product Synonym Names
Anti -Aminoacylase 1 (ACY1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3; NC_000003.11 (52017563..52023218). Location: 3p21.1
OMIM
104620
3D Structure
ModBase 3D Structure for Q03154
Clonality
Monoclonal
Isotype
IgG2B
Clone Number
9L801
Host
Rat
Species Reactivity
Human
Specificity
Recognizes human Aminocyclase. Species sequence homology: chimpanzee (100%), canine (88%), mouse and rat (86%).
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
Immunogen
Purified, insect cell-derived, recombinant human aminoacylase (aa2-408).
Hybridoma
Mouse myeloma cells with B cells obtained from a rat immunized with purified, insect cell-derived, recombinant human aminoacylase (aa2-408).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ACY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACY1 antibody
Aminoacylase (ACY1) is an intracellular soluble homodimeric zinc-binding enzyme. It is involved in the breakdown of acetylated amino acids generated during protein degradation by catalyzing the formation of free aliphatic amino acids from N-acetylated precursors. Mutations in the ACY1 gene might cause inborn metabolic disorders. The aa sequence of human ACY1 is 100%, 88% and 86% identical to that of chimpanzee, dog and mouse/rat.
Product Categories/Family for anti-ACY1 antibody
Applications Tested/Suitable for anti-ACY1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-ACY1 antibody
Suitable for use in ELISA, Western Blot, and Immunoprecipitation.
Dilution: ELISA: 0.5-1ug/ml
Immunoprecipitation: 25ug/ml
Western Blot: 1-2ug/ml
NCBI/Uniprot data below describe general gene information for ACY1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
45,885 Da[Similar Products]
NCBI Official Full Name
Aminoacylase 1
NCBI Official Synonym Full Names
aminoacylase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ACY-1; ACY1D
  [Similar Products]
NCBI Protein Information
aminoacylase-1; OTTHUMP00000212459; OTTHUMP00000212462; OTTHUMP00000212463; OTTHUMP00000212464; OTTHUMP00000220363; N-acyl-L-amino-acid amidohydrolase
UniProt Protein Name
Aminoacylase-1
UniProt Synonym Protein Names
N-acyl-L-amino-acid amidohydrolase
Protein Family
UniProt Gene Name
UniProt Entry Name
ACY1_HUMAN
NCBI Summary for ACY1
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq]
UniProt Comments for ACY1
ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.

Protein type: Hydrolase; Amino Acid Metabolism - arginine and proline; EC 3.5.1.14

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol

Molecular Function: metallopeptidase activity; metal ion binding; aminoacylase activity

Biological Process: amino acid metabolic process; xenobiotic metabolic process; proteolysis

Disease: Aminoacylase 1 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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