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anti-PROS1 antibody :: Anti-Human Protein S Monoclonal Antibody

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Catalog # MBS135099
Unit / Price
  0.1 mg  /  $340 +1 FREE 8GB USB
  0.5 mg  /  $620 +1 FREE 8GB USB
anti-PROS1 antibody
Product Name

Anti-Human Protein S (PROS1), Monoclonal Antibody

Also Known As

Anti-Human Protein S

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
676
Chromosome Location
Chromosome: 3; NC_000003.11 (93591881..93692934, complement). Location: 3q11.2
OMIM
176880
3D Structure
ModBase 3D Structure for P07225
Clonality
Monoclonal
Isotype
IgG1
Clone Number
5092
Host
Host: Mouse; Source: Mouse ascites
Species Reactivity
Human
Purity/Purification
IgG fraction
Form/Format
Liquid
Concentration
5.0 mg/ml (lot specific)
Immunogen
Full length native protein (purified) (Human).
Target Information
Recognises Protein S
Target Molecular Weight
69000
Buffer
50% Glycerol
Extinction Coefficient
1.36
Preparation and Storage
Store at -20 degree C. Shelf Life: 12 months from delivery
Other Notes
Small volumes of anti-PROS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PROS1 antibody
Clone number AHPS-5092. Reactive to: Human protein S. Mouse monoclonal of isotype IgG1.
Applications Tested/Suitable for anti-PROS1 antibody
ELISA (EIA), Radioimmunoassay (RIA), Western Blot (WB), AP
NCBI/Uniprot data below describe general gene information for PROS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,000
NCBI Official Full Name
vitamin K-dependent protein S preproprotein
NCBI Official Synonym Full Names
protein S (alpha)
NCBI Official Symbol
PROS1  [Similar Products]
NCBI Official Synonym Symbols
PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6
  [Similar Products]
NCBI Protein Information
vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S
UniProt Protein Name
Vitamin K-dependent protein S
Protein Family
UniProt Gene Name
PROS1  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
PROS_HUMAN
NCBI Summary for PROS1
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
UniProt Comments for PROS1
PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: Golgi membrane; extracellular space; endoplasmic reticulum membrane; Golgi lumen; plasma membrane; extracellular region

Molecular Function: endopeptidase inhibitor activity; calcium ion binding

Biological Process: platelet activation; fibrinolysis; platelet degranulation; cellular protein metabolic process; regulation of complement activation; innate immune response; blood coagulation; post-translational protein modification; proteolysis; leukocyte migration; peptidyl-glutamic acid carboxylation

Disease: Thrombophilia Due To Protein S Deficiency, Autosomal Recessive; Thrombophilia Due To Protein S Deficiency, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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