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anti-APOA5 antibody :: Mouse anti-Human APOA5 Monoclonal Antibody

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Catalog # MBS600306
Unit / Price
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  0.04 mg  /  $340 +1 FREE 8GB USB
anti-APOA5 antibody
Product Name

APOA5, Monoclonal Antibody

Full Product Name

APOA5 (Apolipoprotein A5, Apo A-V, Apolipoprotein A-V, ApoA-V)

Product Synonym Names
Anti -APOA5 (Apolipoprotein A5, Apo A-V, Apolipoprotein A-V, ApoA-V)
Product Gene Name

anti-APOA5 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 11; NC_000011.9 (116660086..116663136, complement). Location: 11q23
OMIM
144650
3D Structure
ModBase 3D Structure for Q6Q788
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8A105
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human serum total protein in Western Blot and human recombinant Apoa5 in ELISA
Purity/Purification
Ascites
Ascites
Form/Format
Supplied as a liquid (crude ascites)
Immunogen
Ni-NTA purified recombinant human APOA5 expressed in E. coli strain BL21 (DE3)
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-APOA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Categories/Family for anti-APOA5 antibody
Antibodies; Abs to Lipoproteins
Applications Tested/Suitable for anti-APOA5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-APOA5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:2000-1:5000
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NCBI/Uniprot data below describe general gene information for APOA5. It may not necessarily be applicable to this product.
NCBI GI #
262231737
NCBI GeneID
116519
NCBI Accession #
NP_001160070.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001166598.1 [Other Products]
UniProt Primary Accession #
Q6Q788 [Other Products]
UniProt Secondary Accession #
Q3MIK6; Q6UWK9; Q9UBJ3; B0YIV9[Other Products]
UniProt Related Accession #
Q6Q788[Other Products]
Molecular Weight
41,213 Da[Similar Products]
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NCBI Official Full Name
apolipoprotein A-V
NCBI Official Synonym Full Names
apolipoprotein A-V
NCBI Official Symbol
APOA5  [Similar Products]
NCBI Official Synonym Symbols
RAP3; APOAV; FLJ97995; MGC126836; MGC126838
  [Similar Products]
NCBI Protein Information
apolipoprotein A-V; apo-AV; apolipoprotein A5; OTTHUMP00000043271; OTTHUMP00000069351; regeneration-associated protein 3
UniProt Protein Name
Apolipoprotein A-V
UniProt Synonym Protein Names
Apolipoprotein A5; Regeneration-associated protein 3
Protein Family
Apolipoprotein
UniProt Gene Name
APOA5  [Similar Products]
UniProt Synonym Gene Names
RAP3  [Similar Products]
UniProt Entry Name
APOA5_HUMAN
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NCBI Summary for APOA5
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]
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UniProt Comments for APOA5
APOA5: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: extracellular space; chylomicron; extracellular region

Molecular Function: heparin binding; enzyme binding; low-density lipoprotein receptor binding; cholesterol transporter activity; enzyme activator activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; lipid binding

Biological Process: positive regulation of fatty acid biosynthetic process; organ regeneration; response to hormone stimulus; neurite regeneration; cholesterol efflux; positive regulation of lipid catabolic process; lipoprotein metabolic process; cellular lipid metabolic process; lipid transport; cholesterol biosynthetic process; positive regulation of receptor-mediated endocytosis; phosphatidylcholine metabolic process; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; regulation of cholesterol absorption; phospholipid efflux; acylglycerol homeostasis; tissue regeneration; triacylglycerol catabolic process; positive regulation of lipoprotein lipase activity

Disease: Hypertriglyceridemia, Familial; Hyperlipoproteinemia, Type V
Research Articles on APOA5
1. The differences in some serum lipid parameters between the drinkers and nondrinkers might partly result from different interactions of the ApoA5 gene polymorphisms and alcohol consumption.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-APOA5 antibody
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
Diseases associated with anti-APOA5 antibody
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >119 publications with APOA5 and Dyslipidemias
 Hypertriglyceridemia Antibodies  >113 publications with APOA5 and Hypertriglyceridemia
 Myocardial Ischemia Antibodies  >61 publications with APOA5 and Myocardial Ischemia
 Obesity Antibodies  >44 publications with APOA5 and Obesity
 Arteriosclerosis Antibodies  >38 publications with APOA5 and Arteriosclerosis
 Insulin Resistance Antibodies  >33 publications with APOA5 and Insulin Resistance
 Metabolic Syndrome X Antibodies  >25 publications with APOA5 and Metabolic Syndrome X
 Diabetes Mellitus, Type 2 Antibodies  >23 publications with APOA5 and Diabetes Mellitus, Type 2
 Myocardial Infarction Antibodies  >13 publications with APOA5 and Myocardial Infarction
 Central Nervous System Diseases Antibodies  >13 publications with APOA5 and Central Nervous System Diseases
Organs/Tissues associated with anti-APOA5 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >32 publications with APOA5 and Liver
 Lung Antibodies  >1 publications with APOA5 and Lung
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