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anti-ASGR1 antibody :: Rabbit anti-Human ASGR1 Monoclonal Antibody

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Catalog # MBS2544072
Unit / Price
  0.06 mL  /  $215 +1 FREE 8GB USB
  0.12 mL  /  $330 +1 FREE 8GB USB
  0.2 mL  /  $500 +1 FREE 8GB USB
Product Name

ASGR1, Monoclonal Antibody

Popular Item
Also Known As

Rabbit anti Human ASGR1 Monoclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
252
OMIM
M10058 mRNA
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human ASGPR1 protein
Buffer
0.2 mum filtered solution in PBS with 5% trehalose
Calculated MW
32kDa
Observed MW
48kDa
Buffer
PBS with 0.05% sodium azide, 30% glycerol and 5% trehalose
Produce
This antibody was obtained from a rabbit immunized with purified, recombinant Human ASGPR1
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ASGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASGR1 antibody
The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1 (MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
Applications Tested/Suitable for anti-ASGR1 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-ASGR1 antibody
WB: 1:200-1:1000
IP: 1:250-1:1000

Western blot of anti-ASGR1 antibody
Western blot analysis of HepG2 cells using Rabbit anti Human ASGR1 Monoclonal Antibody at dilution of 1:200
anti-ASGR1 antibody Western blot image
IP Result of ASGR1 (IP: MBS2544072,2ug; Detection: MBS2544072 ?dilution of 1:200) with 0.5mg HepG2 ASGR1(A) Rabbit blank IgG(B) cells
anti-ASGR1 antibody IP image
NCBI/Uniprot data below describe general gene information for ASGR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,144 Da
NCBI Official Full Name
asialoglycoprotein receptor 1 isoform b
NCBI Official Synonym Full Names
asialoglycoprotein receptor 1
NCBI Official Symbol
ASGR1  [Similar Products]
NCBI Official Synonym Symbols
HL-1; ASGPR; ASGPR1; CLEC4H1
  [Similar Products]
NCBI Protein Information
asialoglycoprotein receptor 1
UniProt Protein Name
Asialoglycoprotein receptor 1
UniProt Synonym Protein Names
C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1
UniProt Gene Name
ASGR1  [Similar Products]
UniProt Synonym Gene Names
CLEC4H1; ASGP-R 1; ASGPR 1; HL-1  [Similar Products]
UniProt Entry Name
ASGR1_HUMAN
NCBI Summary for ASGR1
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for ASGR1
ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to plasma membrane

Molecular Function: protein binding

Biological Process: receptor-mediated endocytosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-ASGR1 antibody
 Reference Product  PubMed Publications
 ST3GAL4 antibody  >1 publications with ASGR1 and ST3GAL4
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