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anti-ATF2 antibody :: Mouse anti-Human ATF2 Monoclonal Antibody

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Catalog # MBS120012
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

ATF2, Monoclonal Antibody

Popular Item
Also Known As

Mouse monoclonal antibody Anti-Human ATF2

Product Synonym Names
activating transcription factor 2 (ATF2); HB16; CREB2; TREB7; CRE-BP1; MGC111558
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
4193
OMIM
123811
Clonality
Monoclonal
Isotype
IgG1
Clone Number
ATF25I062
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-ATF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATF2 antibody
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-ATF2 antibody
Dot Blot (DB), Immunoprecipitation (IP)

Quality Control of anti-ATF2 antibody
Western blot analysis of immunized recombinant protein, using anti-ATF2 monoclonal antibody.
anti-ATF2 antibody Quality Control image
Quality Control #2 of anti-ATF2 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-ATF2 antibody Quality Control #2 image
Immunoprecipitation (IP) of anti-ATF2 antibody
Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-ATF2 mAb. [Lot No. ATF25I062-1]

Predicted molecular weight: 54 kDa
anti-ATF2 antibody Immunoprecipitation (IP) (IP) image
NCBI/Uniprot data below describe general gene information for ATF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,409 Da
NCBI Official Full Name
Homo sapiens activating transcription factor 2 (ATF2), transcript variant 1, mRNA
NCBI Official Synonym Full Names
activating transcription factor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
HB16; CREB2; TREB7; CREB-2; CRE-BP1
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NCBI Protein Information
cyclic AMP-dependent transcription factor ATF-2; activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; histone acetyltransferase ATF2
UniProt Protein Name
Cyclic AMP-dependent transcription factor ATF-2
UniProt Synonym Protein Names
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
UniProt Gene Name
UniProt Entry Name
ATF2_HUMAN
NCBI Summary for ATF2
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
UniProt Comments for ATF2
ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.

Protein type: C2H2-type zinc finger protein; Transcription factor; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; cAMP response element binding protein binding; transcription coactivator activity; chromatin binding; protein kinase binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to osmotic stress; positive regulation of transforming growth factor-beta2 production; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of transcription factor activity; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; histone acetylation; toll-like receptor 4 signaling pathway; response to DNA damage stimulus
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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