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anti-AURKC antibody :: Mouse anti-Human AURKC Monoclonal Antibody

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Catalog # MBS533542
Unit / Price
  0.1 mL  /  $515 +1 FREE 8GB USB
Product Name

AURKC, Monoclonal Antibody

Popular Item
Also Known As

AURKC antibody

Product Synonym Names
Monoclonal AURKC; Anti-AURKC; Aurora Kinase C; AIE2; AIK3; AurC; STK13; aurora-C
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
275
3D Structure
ModBase 3D Structure for Q5Y191
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10A7
Host
Mouse
Species Reactivity
Human
Purity/Purification
AURKC antibody was purified by affinity chromatography.
Form/Format
Affinity purified fluid in PBS, pH 7.3 with 1% BSA, 50% Glycerol, and 0.02% NaN3
Concentration
1.0 mg/mL (lot specific)
Biological Significance
AURKC may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.
Immunogen
Full length protein expressed in 293T cell transfered with human AURKC expression vector.
Preparation and Storage
4°C shipping. Upon receipt store at -20°C . Avoid repeat freeze-thaw . Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-AURKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AURKC antibody
Mouse monoclonal AURKC antibody
Product Categories/Family for anti-AURKC antibody
Applications Tested/Suitable for anti-AURKC antibody
IF, IHC, WB
Application Notes for anti-AURKC antibody
IF: 1:100
WB: 1:500

Western Blot (WB) of anti-AURKC antibody
Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant AURKC protein (Right) or empty vector (Left) detected with AURKC antibody
anti-AURKC antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AURKC antibody
Immunohistochemical analysis of AURKC protein in paraffin embedded Human endometrium tissue using AURKC antibody
anti-AURKC antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AURKC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
aurora kinase C isoform 3
NCBI Official Synonym Full Names
aurora kinase C
NCBI Official Symbol
AURKC  [Similar Products]
NCBI Official Synonym Symbols
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
  [Similar Products]
NCBI Protein Information
aurora kinase C
UniProt Protein Name
Aurora kinase C
UniProt Synonym Protein Names
Aurora kinase C
Protein Family
UniProt Gene Name
AURKC  [Similar Products]
UniProt Entry Name
Q5Y191_HUMAN
NCBI Summary for AURKC
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for AURKC
AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Other group; AUR family

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: spindle microtubule; cytoplasm; spindle; condensed chromosome; spindle pole centrosome; spindle midzone; midbody; condensed nuclear chromosome, pericentric region

Molecular Function: protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of cytokinesis; spindle midzone assembly involved in mitosis; meiotic cell cycle; histone modification; regulation of signal transduction; cytokinesis; attachment of spindle microtubules to kinetochore; protein amino acid phosphorylation

Disease: Spermatogenic Failure 5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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