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anti-HLA-G antibody :: Mouse anti-Human b2-Microglobulin Monoclonal Antibody

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Catalog # MBS645453
Unit / Price
  0.2 mL  /  $655 +1 FREE 8GB USB
anti-HLA-G antibody
Product Name

b2-Microglobulin (HLA-G), Monoclonal Antibody

Full Product Name

b2-Microglobulin (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P) (HRP)

Product Synonym Names
Anti -b2-Microglobulin (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P) (HRP)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3
OMIM
142871
3D Structure
ModBase 3D Structure for P17693
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
12K274
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human B2M.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in 0.01M PBS, pH 7.0 ± 0.1, 50% glycerol. Labeled with horseradish peroxidase (HRP).
Immunogen
Recombinant corresponding to human B2M.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
Other Notes
Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HLA-G antibody
b2-microglobulin non-covalently associates with the 44kD a-chain to form the HLA Class I antigen complex. Human b2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
Applications Tested/Suitable for anti-HLA-G antibody
ELISA (EL/EIA)
Application Notes for anti-HLA-G antibody
Suitable for use in ELISA.
Dilution: ELISA: 1:1000
NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
38,224 Da[Similar Products]
NCBI Official Full Name
b2 microglobulin
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Symbol
HLA-G  [Similar Products]
NCBI Official Synonym Symbols
MHC-G
  [Similar Products]
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G
UniProt Protein Name
HLA class I histocompatibility antigen, alpha chain G
UniProt Synonym Protein Names
HLA G antigen; MHC class I antigen G
UniProt Gene Name
HLA-G  [Similar Products]
UniProt Synonym Gene Names
HLA-6.0; HLAG  [Similar Products]
UniProt Entry Name
HLAG_HUMAN
NCBI Summary for HLA-G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-G
HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; plasma membrane; MHC class I protein complex

Molecular Function: protein homodimerization activity; peptide antigen binding; receptor binding

Biological Process: immune response-inhibiting cell surface receptor signaling pathway; regulation of immune response; positive regulation of regulatory T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tolerance induction; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of T cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular defense response; positive regulation of T cell tolerance induction

Disease: Asthma, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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