• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-VTCN1 antibody :: Mouse anti-Human B7H4 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS604931
Unit / Price
  0.1 mg  /  $465 +1 FREE 8GB USB
anti-VTCN1 antibody
Product Name

B7H4 (VTCN1), Monoclonal Antibody

Popular Item
Also Known As

B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)

Product Synonym Names
Anti -B7H4 (B7-H4, B7S1, B7x, BC032925, Immune Costimulatory Protein B7H4, MGC41287, PRO1291, T Cell Costimulatory Molecule B7x, V Set Domain-containing T Cell Activation Inhibitor 1, VCTN1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 1; Location: 1p13.1
3D Structure
ModBase 3D Structure for Q5T2L0
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10B249
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human B7H4.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Concentration
1mg/ml (lot specific)
Immunogen
Human B7H4
Positive Control
Immunohistochemistry: Tonsil, breast carcinoma
Negative Control
I1904-78R: IgG1 Murine Negative Control
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-VTCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forVTCN1purchase
VTCN 1 binds ligands and can also bind a VTCN1 antibody and elicit biological responses in cells. Immunology is in a renaissance and by supplying world leading antibodies for IHC, ELISA or WB, we aim to capture your labs exclusive reagent needs whether your model is rat, mouse, rabbit, goat or human cell types. When your needs turn to FACS analysis, use our monoclonal mouse anti B7 H4 VTCN1 antibodies clone MIH to label in red to sort for cell activation or green for cell activation inhibitor sorting. We offer a full panel of anti VTCN1 protein IgG antibodies and include our current mo FACS datasheet describing up to the moment protocols. Go to MyBiosource.com for catalog numbers and ordering information for mouse anti VTCN1, rat anti VTCN1, rabbit anti VTCN1 antibody and anti human B7 antibody polyclonal antibodies. Combine your order with goat anti mouse IgG and instant experiment.
Related Product Information for
anti-VTCN1 antibody
B7H4, also known as B7x, is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7H4 deficient mice are only minimally affected; suggesting B7H4 is important in the fine tuning of the T-cell mediated immune response.

B7H4 is expressed on activate T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung. breast and ovary in humans. B7H4could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
Product Categories/Family for anti-VTCN1 antibody
Applications Tested/Suitable for anti-VTCN1 antibody
Immunohistochemistry (IHC), Flow Cytometry (FC/FACS).
Other applications not tested.
Application Notes for anti-VTCN1 antibody
Suitable for use in Flow Cytometry and Immunohistochemistry.
Dilution: Flow Cytometry: 1:25-1:50; 10ul labels 10e6 cells in 100ul.
Immunohistochemistry (Paraffin): 1:50. Does not require protein digestion pre-treatment of paraffin sections. Does not require antigen retrieval using heat treatment prior to staining paraffin sections.
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for VTCN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
31,259 Da[Similar Products]
NCBI Official Full Name
B7-H4 protein
NCBI Official Synonym Full Names
V-set domain containing T cell activation inhibitor 1
NCBI Official Symbol
VTCN1  [Similar Products]
NCBI Official Synonym Symbols
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; FLJ22418; RP11-229A19.4; VTCN1
  [Similar Products]
NCBI Protein Information
V-set domain-containing T-cell activation inhibitor 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4
UniProt Protein Name
Uncharacterized protein
UniProt Gene Name
VTCN1  [Similar Products]
UniProt Entry Name
Q5T2L0_HUMAN
NCBI Summary for VTCN1
B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]
UniProt Comments for VTCN1
VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: response to protozoan; immune system process; positive regulation of T cell proliferation; negative regulation of T cell activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-VTCN1 antibody
 Reference Product  PubMed Publications
 BTLA antibody  >3 publications with VTCN1 and BTLA
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000