• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-BAP1 antibody :: Mouse anti-Human BAP1 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS120218
Unit / Price
  0.1 mg  /  $345 +1 FREE 8GB USB
Product Name

BAP1, Monoclonal Antibody

Also Known As

Mouse monoclonal antibody Anti-Human BAP1

Product Synonym Names
Homo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1); hucep-6; FLJ35406;FLJ37180; HUCEP-13; KIAA0272; DKFZp686N04275
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3717
OMIM
156240
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2058C3a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-BAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BAP1 antibody
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-BAP1 antibody
Dot Blot (DB), Immunocytochemistry (ICC)

Quality Control of anti-BAP1 antibody
Western blot analysis of immunized recombinant protein, using anti-BAP1 monoclonal antibody.
anti-BAP1 antibody Quality Control image
Quality Control #2 of anti-BAP1 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-BAP1 antibody Quality Control #2 image
Immunocytochemistry (ICC) of anti-BAP1 antibody
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-BAP1 mAb. [Lot No.2058C3a-1]
anti-BAP1 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for BAP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,362 Da
NCBI Official Full Name
Homo sapiens BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1), mRNA
NCBI Official Synonym Full Names
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
NCBI Official Symbol
NCBI Official Synonym Symbols
UCHL2; hucep-6; HUCEP-13
  [Similar Products]
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase BAP1; cerebral protein 6; cerebral protein-13
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase BAP1
UniProt Synonym Protein Names
BRCA1-associated protein 1; Cerebral protein 6
Protein Family
UniProt Gene Name
UniProt Entry Name
BAP1_HUMAN
NCBI Summary for BAP1
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
UniProt Comments for BAP1
BAP1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily.

Protein type: Ubiquitin conjugating system; Protease; Ubiquitin-specific protease; EC 3.4.19.12; Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: peptidase activity; protein binding; ubiquitin-specific protease activity; chromatin binding

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; protein modification process; regulation of cell growth

Disease: Tumor Predisposition Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000