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anti-F7 antibody :: Biotin Labeled Anti Human Factor VII, Clone 11G42D8 Monoclonal Antibody

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Catalog # MBS135106
Unit / Price
  1 mg  /  $665 +1 FREE 8GB USB
  10 mg  /  $4,450 +5 FREE 8GB USB
anti-F7 antibody
Product Name

Biotin Labeled Anti Human Factor VII, Clone 11G42D8 (F7), Monoclonal Antibody

Popular Item
Also Known As

Biotin Labeled Anti Human Factor VII, Clone 11G42D8

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
466
Chromosome Location
Chromosome: 13; NC_000013.10 (113760102..113774995). Location: 13q34
OMIM
227500
3D Structure
ModBase 3D Structure for P08709
Clonality
Monoclonal
Isotype
IgG2b kappa
Clone Number
11G42-D8
Host
Host: Mouse; Source: Hybridoma cell culture
Species Reactivity
Human
Purity/Purification
IgG fraction
Form/Format
Frozen liquid
Concentration
6.4 mg/ml (lot specific)
Immunogen
Full length native protein (purified) (Human).
Target Information
Recognises Factor VII
Target Molecular Weight
50000
Buffer
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Extinction Coefficient
1.36
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Other Notes
Small volumes of anti-F7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-F7 antibody
Biotin labeled mouse monoclonal antibody to Human Factor VII. IgG fraction purified by immobilized Protein G. Isotype IgG2bKappa.
Applications Tested/Suitable for anti-F7 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for F7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,000
NCBI Official Full Name
coagulation factor VII isoform a preproprotein
NCBI Official Synonym Full Names
coagulation factor VII (serum prothrombin conversion accelerator)
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor VII; eptacog alfa; proconvertin; FVII coagulation protein
UniProt Protein Name
Coagulation factor VII
UniProt Synonym Protein Names
Proconvertin; Serum prothrombin conversion accelerator
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
FA7_HUMAN
NCBI Summary for F7
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for F7
F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Apoptosis; Motility/polarity/chemotaxis; Secreted, signal peptide; EC 3.4.21.21; Secreted

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region; plasma membrane; vesicle

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding

Biological Process: circadian rhythm; organ regeneration; positive regulation of positive chemotaxis; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; post-translational protein modification; proteolysis; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; response to vitamin K; response to estrogen stimulus; blood coagulation; positive regulation of cell migration

Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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