NP_114172.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,102 Da
NCBI Official Full Name
Homo sapiens cyclin B1 (CCNB1), mRNA
NCBI Official Synonym Full Names
cyclin B1
NCBI Official Synonym Symbols
NCBI Protein Information
G2/mitotic-specific cyclin-B1; G2/mitotic-specific cyclin B1
UniProt Protein Name
G2/mitotic-specific cyclin-B1
UniProt Entry Name
CCNB1_HUMAN
NCBI Summary for CCNB1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]
UniProt Comments for CCNB1
CCNB1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase.
Protein type: Cell cycle regulation; Activator
Chromosomal Location of Human Ortholog: 5q12
Cellular Component: nucleoplasm; spindle pole; centrosome; membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; patched binding; histone kinase activity; protein kinase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of histone phosphorylation; regulation of cell cycle; ventricular cardiac muscle cell development; positive regulation of attachment of spindle microtubules to kinetochore; mitotic nuclear envelope disassembly; positive regulation of mRNA 3'-end processing; positive regulation of mitotic cell cycle; positive regulation of fibroblast proliferation; negative regulation of protein amino acid phosphorylation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; tissue regeneration; protein complex assembly; G2/M transition of mitotic cell cycle; positive regulation of cardiac muscle cell proliferation; response to drug; in utero embryonic development; oocyte maturation; mitotic metaphase plate congression; response to DDT; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; gut development; response to mechanical stimulus; cell division; spermatogenesis; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; mitotic spindle stabilization; G1/S transition of mitotic cell cycle
Research Articles on CCNB1
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Products associated with anti-CCNB1 antibody
Pathways associated with anti-CCNB1 antibody
Diseases associated with anti-CCNB1 antibody
Organs/Tissues associated with anti-CCNB1 antibody
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