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anti-ITGAX antibody :: Mouse CD11c Monoclonal Antibody

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Catalog # MBS439537
Unit / Price
  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
anti-ITGAX antibody
Product Name

CD11c (ITGAX), Monoclonal Antibody

Popular Item
Also Known As

CD11c (Dendritic Cell Marker) Mouse Monoclonal Antibody

Product Synonym Names
CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1163
OMIM
151510
3D Structure
ModBase 3D Structure for P20702
Clonality
Monoclonal
Isotype
IgG2b, kappa
Host
Mouse
Species Reactivity
Human.Others not known.
Specificity
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Cellular Localization
Cell Surface
Immunogen
Recombinant human ITGAX protein fragment (aa 637-827)
Hu-Chromosome Location
16p11.2
Positive Control
Human dendritic cells. Human lymph nodes and tonsils.
Preparation and Storage
Antibody with azide - store at 2 to 8°C.
Other Notes
Small volumes of anti-ITGAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ITGAX antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-ITGAX antibody
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1ug/mL)
Immunohistology (Formalin-fixed)(1-2ug/mL for 30 min at RT)
Staining of formalin-fixxed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.

Optimal dilution for specific application should be determined.
NCBI/Uniprot data below describe general gene information for ITGAX. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
145kDa
NCBI Official Full Name
integrin alpha-X isoform 2
NCBI Official Synonym Full Names
integrin subunit alpha X
NCBI Official Symbol
ITGAX  [Similar Products]
NCBI Official Synonym Symbols
CD11C; SLEB6
  [Similar Products]
NCBI Protein Information
integrin alpha-X
UniProt Protein Name
Integrin alpha-X
UniProt Synonym Protein Names
CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c
Protein Family
UniProt Gene Name
ITGAX  [Similar Products]
UniProt Synonym Gene Names
CD11C  [Similar Products]
UniProt Entry Name
ITAX_HUMAN
NCBI Summary for ITGAX
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for ITGAX
ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; organ morphogenesis

Disease: Systemic Lupus Erythematosus
Product References and Citations for anti-ITGAX antibody
Nicolaou, F., et al. 2003. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes Ras and JunD. Blood 101: 4033-4041

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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