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anti-BSG antibody :: anti-Human CD147 (Neurothelin) Monoclonal Antibody

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Catalog # MBS312130
Unit / Price
  0.2 mg  /  $750 +1 FREE 8GB USB
anti-BSG antibody
Product Name

CD147 (Neurothelin) (BSG), Monoclonal Antibody

Also Known As

MAb to CD147

Product Synonym Names
Monoclonal Antibody to Human CD147 (Neurothelin)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (571325..583493). Location: 19p13.3
3D Structure
ModBase 3D Structure for Q54A51
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MEM-M6/1
Host
Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.
Source: Ascites
Species Reactivity
Human
Specificity
CD147 (Neurothelin)
Recognizes human CD147. Reacts with an epitope in the N-terminal Ig domain (D1). Recognizes a 50-60 kDa glycoprotein also known as neurothelin and basigin. CD147 is expressed on peripheral blood cells and by endothelial cells. Expre
Purity/Purification
Protein A chromatography
Form/Format
Purified, Liquid
Concentration
1mg/ml (OD280nm) (lot specific)
Immunogen
Soluble recombinant CD147Rg (extracellular region)
Affinity Constant
1.91 x 10^10
Buffer
PBS, pH 7.4
Preservative
0.05% Sodium azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Short term, store at 2 to 8 degree C. Long term, aliquot and store at -20 degree C. Avoid multiple freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BSG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BSG antibody
Flow Cytometry, Western Blot
NCBI/Uniprot data below describe general gene information for BSG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
29,221 Da[Similar Products]
NCBI Official Full Name
CD147
NCBI Official Synonym Full Names
basigin (Ok blood group)
NCBI Official Symbol
NCBI Official Synonym Symbols
M6; OK; 5F7; TCSF; CD147; EMMPRIN
  [Similar Products]
NCBI Protein Information
basigin; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6; extracellular matrix metalloproteinase inducer; tumor cell-derived collagenase stimulatory factor
UniProt Protein Name
Basigin (Ok blood group), isoform CRA_a
Protein Family
UniProt Gene Name
hEMMPRIN  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
Q54A51_HUMAN
NCBI Summary for BSG
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for BSG
BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi membrane; focal adhesion; membrane; mitochondrion; integral to plasma membrane; plasma membrane; melanosome; sarcolemma; lipid raft; acrosomal membrane

Molecular Function: mannose binding; protein binding

Biological Process: response to mercury ion; extracellular matrix disassembly; response to peptide hormone stimulus; cellular metabolic process; extracellular matrix organization and biogenesis; response to cAMP; cell surface receptor linked signal transduction; decidualization; blood coagulation; pyruvate metabolic process; leukocyte migration; embryo implantation; odontogenesis of dentine-containing teeth

Disease: Blood Group--ok
Product References and Citations for anti-BSG antibody
• Koch, C., et al., (1999), "T cell activation-associated epitopes of CD147 in regulation of the T cell response and their definition by antibody affinity and antigen density", International Immunology, 11(5): 777-786.
• Reimers, N.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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