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anti-CD16 antibody :: Mouse anti-Human CD16 Monoclonal Antibody

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Catalog # MBS530474
Unit / Price
  0.1 mg  /  $360 +1 FREE 8GB USB
anti-CD16 antibody
Product Name

CD16, Monoclonal Antibody

Also Known As

CD16 antibody

Product Synonym Names
Monoclonal CD16; Anti-CD16; CD-16; CD 16; FcgRIII; CD16 FcgRIII; CD16
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
233
OMIM
146740
3D Structure
ModBase 3D Structure for P08637
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3G8
Host
Mouse
Species Reactivity
Human
Purity/Purification
> 95% pure
CD16 antibody was purified by Protein A chromatography.
Form/Format
50mM Na3PO4, pH 7.5, with 100mM KCL, 150mM NaCl, and 0.5 mg/ml gentamycin sulfate.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphtidyl inositol (GPI) anchored protein in granulocytes, and as an integral membrane protein on NK cells and macrophages.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
CD16 antibody was raised in mouse using human polymorphonuclear leukocytes as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-CD16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD16 antibody
Mouse monoclonal CD16 antibody
Product Categories/Family for anti-CD16 antibody
Applications Tested/Suitable for anti-CD16 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD16 antibody
FC: 5 ug/ml
NCBI/Uniprot data below describe general gene information for CD16. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,089 Da
NCBI Official Full Name
CD16, partial
NCBI Official Synonym Full Names
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Official Symbol
FCGR3A  [Similar Products]
NCBI Official Synonym Symbols
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
  [Similar Products]
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Synonym Protein Names
CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
Protein Family
UniProt Gene Name
FCGR3A  [Similar Products]
UniProt Synonym Gene Names
CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa  [Similar Products]
UniProt Entry Name
FCG3A_HUMAN
NCBI Summary for CD16
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CD16
FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: IgG binding

Biological Process: regulation of immune response; innate immune response; immune response

Disease: Immunodeficiency 20
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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