AAB33925.2
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,089 Da
NCBI Official Full Name
CD16, partial
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIIa
NCBI Official Synonym Symbols
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA [Similar Products]
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor III-A
UniProt Synonym Protein Names
CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a
UniProt Synonym Gene Names
CD16A; FCG3; FCGR3; IGFR3; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa [Similar Products]
NCBI Summary for CD16
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CD16
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Product References and Citations for anti-CD16 antibody
1.Knapp, W., et al. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York. 2.Stroncek, D.F., et al. (1991) Blood 77:1572. 3.Wirthmueller, U., et al. (1992) J. Exp. Med. 175:1381. 4.Barclay, N.A., et al. (1993) The Leucocyte Antigen FactBook, CD16 section, Academic Press Inc., San Diego, Calfornia, p. 136.
Research Articles on CD16
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Products associated with anti-CD16 antibody
Pathways associated with anti-CD16 antibody
Diseases associated with anti-CD16 antibody
Organs/Tissues associated with anti-CD16 antibody
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