BAA12019.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,179 Da
NCBI Official Full Name
RP105
NCBI Official Synonym Full Names
CD180 molecule
NCBI Protein Information
CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa
UniProt Protein Name
CD180 antigen
UniProt Synonym Protein Names
Lymphocyte antigen 64; Radioprotective 105 kDa protein
UniProt Synonym Gene Names
UniProt Entry Name
CD180_HUMAN
NCBI Summary for CD180 (TLR4/RP105)
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
UniProt Comments for CD180 (TLR4/RP105)
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells
By similarity.
Subunit structure: M-shaped tetramer of two CD180-LY86 heterodimers. Ref.9
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
Research Articles on CD180 (TLR4/RP105)
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Pathways associated with anti-CD180 (TLR4/RP105) antibody
Diseases associated with anti-CD180 (TLR4/RP105) antibody
Organs/Tissues associated with anti-CD180 (TLR4/RP105) antibody
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