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anti-CD1A antibody :: Rabbit CD1a/HTA1 Monoclonal Antibody

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Catalog # MBS4380303
Unit / Price
Scan QR to view Datasheet
  0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
  0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
  0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
Product Name

CD1a/HTA1, Monoclonal Antibody

Popular Item
Full Product Name

CD1a/HTA1 (Mature Langerhans Cells Marker)

Product Synonym Names
Cortical thymocyte antigen CD1A; Epidermal dendritic cell marker CD1a antibody; FCB6; HTA1; T cell surface antigen T6 / Leu 6; T-Cell Surface Glycoprotein CD1A
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06126
Clonality
Monoclonal
Isotype
IgG
Clone Number
C1A/1506R
Host
Rabbit
Species Reactivity
Human. Others not known.
Specificity
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa). 
Form/Format
200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunogen
Recombinant full-length human CD1a protein
Cellular Localization
Cell Surface
Hu-chromosome Location
1q23.1
Positive Control
MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Other Notes
Small volumes of anti-CD1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CD1A antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-CD1A antibody
FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-CD1A antibody
Formalin-fixed, paraffin-embedded human Skin stained with CD1a Rabbit Recombinant Monoclonal Antibody (C1A/1506R).
anti-CD1A antibody Immunohistochemistry (IHC) (IHC) image
SDS-Page of anti-CD1A antibody
SDS-PAGE Analysis of Purified CD1a Rabbit Recombinant Monoclonal Antibody (C1A/1506R).
anti-CD1A antibody SDS-Page image
NCBI/Uniprot data below describe general gene information for CD1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49kDa
NCBI Official Full Name
T-cell surface glycoprotein CD1a isoform 2
NCBI Official Synonym Full Names
CD1a molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
R4; T6; CD1; FCB6; HTA1
  [Similar Products]
NCBI Protein Information
T-cell surface glycoprotein CD1a
UniProt Protein Name
T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names
T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a
UniProt Gene Name
UniProt Synonym Gene Names
hTa1 thymocyte antigen  [Similar Products]
NCBI Summary for CD1A
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for CD1A
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Product References and Citations for anti-CD1A antibody
Cassaday, RD.et al.2007. Clin. Cancer Res. 13: 540-549. Matsuda, A.et al.2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877. Gulubova, M.et al.2008. Clin. Exp. Metastasis. 25: 777-785. McNally, AK.et al.2011. Exp. Mol. Pathol. 91: 673-681.

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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