• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CD28 antibody :: anti-Human CD28 Monoclonal Antibody

Scan QR to view Datasheet
Catalog # MBS2534403
Unit / Price
  0.05 mg  /  $145 +1 FREE 8GB USB
  0.5 mg  /  $395 +1 FREE 8GB USB
  1 mg  /  $575 +1 FREE 8GB USB
anti-CD28 antibody
Product Name

CD28, Monoclonal Antibody

Full Product Name

LE/AF Purified Anti-Human CD28 Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Monoclonal
Isotype
IgG1
Clone Number
CD28.2
Species Reactivity
Human
Form/Format
PBS pH 7.2, 0.09% NaN3, 0.2% BSA
Concentration
1 mg/ml (lot specific)
Conjugation
LE/AF
Preparation and Storage
Keep as concentrated solution. Store at 4 degree C as an undiluted liquid. For extended storage aliquot contents and freeze at -20 degree C or lower. Avoid cycles of freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CD28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD28 antibody
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
NCBI/Uniprot data below describe general gene information for CD28. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,243 Da
NCBI Official Full Name
CD28, partial
NCBI Official Synonym Full Names
CD28 antigen
NCBI Official Symbol
NCBI Protein Information
T-cell-specific surface glycoprotein CD28
UniProt Protein Name
T-cell-specific surface glycoprotein CD28
UniProt Synonym Protein Names
CD_antigen: CD28
UniProt Gene Name
UniProt Entry Name
CD28_MOUSE
UniProt Comments for CD28
CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: external side of plasma membrane; immunological synapse; integral to membrane; lipid raft; membrane; plasma membrane

Molecular Function: protease binding; protein homodimerization activity; protein kinase binding; SH3/SH2 adaptor activity

Biological Process: immune response; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response to antigenic stimulus; positive regulation of interleukin-2 biosynthetic process; positive regulation of isotype switching to IgG isotypes; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of regulatory T cell differentiation; regulatory T cell differentiation; T cell activation; T cell costimulation; T cell receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000