NP_001234.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,935 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 8 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 8
NCBI Protein Information
tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 8
UniProt Synonym Protein Names
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
UniProt Synonym Gene Names
UniProt Entry Name
TNR8_HUMAN
NCBI Summary for CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for CD30
TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: cytoplasm; integral to membrane; plasma membrane
Molecular Function: transmembrane receptor activity
Biological Process: negative regulation of cell proliferation; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction
Research Articles on CD30
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Products associated with anti-CD30 antibody
Pathways associated with anti-CD30 antibody
Diseases associated with anti-CD30 antibody
Organs/Tissues associated with anti-CD30 antibody
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