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anti-CD36 antibody :: anti-Human CD36 Monoclonal Antibody

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Catalog # MBS311750
Unit / Price
  0.2 mg  /  $350 +1 FREE 8GB USB
anti-CD36 antibody
Product Name

CD36, Monoclonal Antibody

Also Known As

MAb to CD36

Product Synonym Names
Monoclonal Antibody to Human CD36
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
472
Chromosome Location
Chromosome: 7; NC_000007.13 (80231504..80308593). Location: 7q11.2
OMIM
173510
3D Structure
ModBase 3D Structure for P16671
Clonality
Monoclonal
Isotype
IgM
Clone Number
289-10930 (SM?)
Host
Host: Mouse
Source: Tissue Culture
Species Reactivity
Human
Specificity
CD36
Human CD36
Purity/Purification
>90% pure (SDS-PAGE). S-300 Sepharose size exclusion chromatography.
Form/Format
Purified, Liquid
Concentration
1.0mg/ml (OD280nm, E^0.1% = 1.2) (lot specific)
Immunogen
Human tonsil cells and PBM
Affinity Constant
Not determined
Buffer
10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
Preservative
0.1% Sodium Azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,053 Da[Similar Products]
NCBI Official Full Name
CD36
NCBI Official Synonym Full Names
CD36 molecule (thrombospondin receptor)
NCBI Official Symbol
NCBI Official Synonym Symbols
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3
  [Similar Products]
NCBI Protein Information
platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)
UniProt Protein Name
Platelet glycoprotein 4
UniProt Synonym Protein Names
Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GP3B; GP4  [Similar Products]
UniProt Entry Name
CD36_HUMAN
NCBI Summary for CD36
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
UniProt Comments for CD36
Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22

Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12

Subcellular location: Membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16

Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection.

Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[

MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [

MIM:610938]. Ref.23

Sequence similarities: Belongs to the CD36 family.

Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.
Product References and Citations for anti-CD36 antibody
• Hogg, N.H. et al (1984) Immunology 53:753
• Linch, D.C et al (1984) Blood 63:566

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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