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anti-CD63 antibody :: Mouse anti-Human CD63 Monoclonal Antibody

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Catalog # MBS335647
Unit / Price
  0.2 mg  /  $365 +1 FREE 8GB USB
Testing Data
Product Name

CD63, Monoclonal Antibody

Popular Item
Also Known As

Mouse Anti-Human CD63 Monoclonal Antibody, Azide Free Clone TS63

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (56119227..56123457, complement). Location: 12q12-q13
OMIM
155740
3D Structure
ModBase 3D Structure for P08962
Clonality
Monoclonal
Isotype
IgG1
Clone Number
TS63
Host
Mouse
Species Reactivity
Human
Specificity
Recognises the LIMP antigen, a 30-60 kDa (smear) protein
Purity/Purification
Ion exchange chromatography
Form/Format
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
Concentration
200ug / 200ul (lot specific)
Antigen
CD63
Hybridoma
Myeloma X63/AG8. x Balb/c spleen cells
Immunization
Jurkat and HEL cell lines
Conjugate
Azide free
Preparation and Storage
Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots
Other Notes
Small volumes of anti-CD63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CD63 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)

Testing Data of anti-CD63 antibody
1,3 105 HEL cells were lysed (lysis buffer containing 1% Brij97 or triton) Migration SDS/page 5-15% gel under non-reducing conditions
anti-CD63 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD63. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,637 Da
NCBI Official Full Name
CD63 antigen isoform D
NCBI Official Synonym Full Names
CD63 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
  [Similar Products]
NCBI Protein Information
CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3
UniProt Protein Name
CD63 antigen
UniProt Synonym Protein Names
Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MLA1; TSPAN30; LAMP-3; Tspan-30  [Similar Products]
UniProt Entry Name
CD63_HUMAN
NCBI Summary for CD63
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
UniProt Comments for CD63
Function: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.

Subcellular location: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Ref.3 Ref.13 Ref.15 Ref.17 Ref.18

Tissue specificity: Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

Miscellaneous: Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Sequence similarities: Belongs to the tetraspanin (TM4SF) family.
Product References and Citations for anti-CD63 antibody
• Charrin et.al Eur J Immunol 2003
• Charrin et.al FEBS lett 2002
• Charrin et.al. J Biol Chem 2001
• Sordat et.al Lab Invest 2002

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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