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anti-CEACAM8 antibody :: Mouse anti-Human CEACAM8 Monoclonal Antibody

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Catalog # MBS468020
Unit / Price
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  0.1 mg  /  $505 +1 FREE 8GB USB
Product Name

CEACAM8, Monoclonal Antibody

Full Product Name

anti-human CEACAM8 monoclonal antibody

Product Synonym Names
CD66b; NCA-95
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31997
Clone Number
Species Reactivity
anti-human CEACAM8 (CD66b/NCA-95)
Protein G
phosphate buffered saline, pH 7.2
genetic immunisation with cDNA encoding human CEACAM8
based on recognition of the complete native protein expressed on transfected mammalian cells
Preparation and Storage
Short term: 2 degree C - 8 degree C; long term: -20 degree C (avoid repeated freezing and thawing)
Other Notes
Small volumes of anti-CEACAM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CEACAM8 antibody
Background: CEA-related cell adhesion molecule 8 (CEACAM8, CD66b) belongs to the carcinoembryonic antigen (CEA) gene family (1,3,4). It encodes a glycosylphosphatidylinositol (GPI)-linked glycoprotein with a Mr of 95,000 which is expressed in cells of the granulocyte-lineage. It is expressed in neutrophils and eosinophils and is characterized as a granulocyte-specific activation antigen. CEACAM8 could serve as a marker for granulocyte activities (2). Like all members of the CEA family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A and B domains.
Applications Tested/Suitable for anti-CEACAM8 antibody
Flow Cytometry (FC/FACS), CELISA, ELISA (EIA)
Application Notes for anti-CEACAM8 antibody
Flow Cytometry: 1.2 ug/10^6 cells
CELISA: 1:200 - 1:400

Testing Data of anti-CEACAM8 antibody
Fig.1: FACS analysis of BOSC23 cells using GM2H6 Cat.# GM- 0512. BOSC23 cells were transiently transfected with an expression vector encoding either CEACAM8 (red curve) or an irrelevant protein (control transfectant). Binding of GM-0512 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with CEACAM8 transfected cells.
anti-CEACAM8 antibody Testing Data image
Testing Data #2 of anti-CEACAM8 antibody
Fig. 2: BOSC23 cells were transiently transfected with expression vectors containing either the cDNA of CEACAM1, CEACAM3-8 or PSG. The latter expressed as a membrane bound fusion protein. Expression of the constructs was tested with monoclonal antibodies known to recognize the corresponding proteins (CEACAM1,3,4,5 and 6: D14HD11; CEACAM7: BAC2; CEACAM8: Tet2; PSG: BAP3; green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G-purified GM-2H6 was tested on all CEACAM transfectants. A positive signal was obtained only with CEACAM8 transfected cells (red curve).
anti-CEACAM8 antibody Testing Data #2 image
NCBI/Uniprot data below describe general gene information for CEACAM8. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,154 Da[Similar Products]
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 8
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 8
NCBI Official Symbol
CEACAM8  [Similar Products]
NCBI Official Synonym Symbols
CD67; CGM6; CD66b; NCA-95
  [Similar Products]
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 8; CD67 antigen; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; carcinoembryonic antigen gene family member 6
UniProt Synonym Protein Names
CD67 antigen; Carcinoembryonic antigen CGM6; Non-specific cross-reacting antigen NCA-95; CD_antigen: CD66b
UniProt Gene Name
CEACAM8  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
UniProt Comments for CEACAM8
CEACAM8: Belongs to the immunoglobulin superfamily. CEA family.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Biological Process: immune response; blood coagulation; leukocyte migration
Product References and Citations for anti-CEACAM8 antibody
1. Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
2. Zhao L, Xu S, Fjaertoft G, Pauksen K, Hakansson L and Venge P (2004). An enzyme-linked immunosorbent assay for human carcinoembryonic antigen-related cell adhesion molecule 8, a biological marker of granulocyte activities in vivo. J. Immunol. Methods 293(1-2):207-14
Hammarström S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81.

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