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anti-CHRDL1 antibody :: Mouse anti-Human Chordin-like Protein 1 Monoclonal Antibody

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Catalog # MBS608882
Unit / Price
  0.1 mL  /  $685 +1 FREE 8GB USB
anti-CHRDL1 antibody
Product Name

Chordin-like Protein 1 (CHRDL1), Monoclonal Antibody

Also Known As

Chordin-like Protein 1 (CHL, CHRDL1, dA141H5.1, Neuralin-1, NRLN1, Neurogenesin-1, Ventroptin, VOPT) (Azide Free)

Product Synonym Names
Anti -Chordin-like Protein 1 (CHL, CHRDL1, dA141H5.1, Neuralin-1, NRLN1, Neurogenesin-1, Ventroptin, VOPT) (Azide Free)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: X; NC_000023.10 (109917084..110039286, complement). Location: Xq23
3D Structure
ModBase 3D Structure for Q59FB2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10B2236
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human CHRDL1.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Immunogen
Recombinant protein corresponding to a portion of amino acids within aa347-457 of human CHRDL1.
Hybridoma
Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CHRDL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHRDL1 antibody
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
Applications Tested/Suitable for anti-CHRDL1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CHRDL1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
ELISA: 1ug/ml-3ng/ml
NCBI/Uniprot data below describe general gene information for CHRDL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
49,664 Da[Similar Products]
NCBI Official Full Name
chordin-like protein 1 isoform 1
NCBI Official Synonym Full Names
chordin-like 1
NCBI Official Symbol
CHRDL1  [Similar Products]
NCBI Official Synonym Symbols
CHL; VOPT; NRLN1; dA141H5.1
  [Similar Products]
NCBI Protein Information
chordin-like protein 1; neuralin 1; neuralin-1; ventroptin; neurogenesin-1; OTTHUMP00000023853; OTTHUMP00000023854; OTTHUMP00000216337; OTTHUMP00000216338; OTTHUMP00000226627
UniProt Protein Name
Chordin-like 1 variant
Protein Family
UniProt Entry Name
Q59FB2_HUMAN
NCBI Summary for CHRDL1
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
UniProt Comments for CHRDL1
CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: extracellular region

Biological Process: BMP signaling pathway; neuron differentiation; ossification; eye development; compound eye development; negative regulation of BMP signaling pathway

Disease: Megalocornea
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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