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anti-C5 antibody :: Mouse anti-Human Complement C5, C5b Monoclonal Antibody

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Catalog # MBS605642
Unit / Price
  0.1 mg  /  $690 +1 FREE 8GB USB
anti-C5 antibody
Product Name

Complement C5, C5b, Monoclonal Antibody

Popular Item
Also Known As

Complement C5, C5b

Product Synonym Names
Anti -Complement C5, C5b
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000009.11 (123714613..123812554, complement). Location: 9q33-q34
OMIM
120900
3D Structure
ModBase 3D Structure for P01031
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
6A536
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes an epitope on human C5 and on C5b.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 0.02% sodium azide.
Concentration
0.1mg/ml (lot specific)
Immunogen
Human Complement C5b.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C5 antibody
C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5 into C5a and C5b. C5b initiates the assembly of the membrane attack complex (MAC) that mediates cytolysis.
Product Categories/Family for anti-C5 antibody
Applications Tested/Suitable for anti-C5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-C5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:10
NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
188,305 Da[Similar Products]
NCBI Official Full Name
complement C5 preproprotein
NCBI Official Synonym Full Names
complement component 5
NCBI Official Symbol
NCBI Official Synonym Symbols
CPAMD4; FLJ17816; FLJ17822; MGC142298
  [Similar Products]
NCBI Protein Information
complement C5; OTTHUMP00000022001; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
UniProt Protein Name
Complement C5
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPAMD4  [Similar Products]
UniProt Entry Name
CO5_HUMAN
NCBI Summary for C5
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq]
UniProt Comments for C5
C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: membrane attack complex; extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; endopeptidase inhibitor activity; C5a anaphylatoxin chemotactic receptor binding; receptor binding

Biological Process: activation of MAPK activity; in utero embryonic development; positive regulation of chemotaxis; cytolysis; complement activation, alternative pathway; chemotaxis; glucose homeostasis; leukocyte migration during inflammatory response; complement activation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of complement activation; response to stress; innate immune response; inflammatory response; negative regulation of dopamine secretion; complement activation, classical pathway

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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