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anti-BMPER antibody :: Rat anti-Human Crossveinless 2 Monoclonal Antibody

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Catalog # MBS601225
Unit / Price
  0.1 mg  /  $630 +1 FREE 8GB USB
anti-BMPER antibody
Product Name

Crossveinless 2 (BMPER), Monoclonal Antibody

Also Known As

Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)

Product Synonym Names
Anti -Crossveinless 2 (CV2, CV-2, CRIM3, BMP-Binding Endothelial Regulator Protein Precursor, BMPER2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 7; Location: 7p14.3
OMIM
608699
3D Structure
ModBase 3D Structure for Q8N8U9
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H123
Host
Rat
Species Reactivity
Human
Specificity
Recognizes human Crossveinless-2.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Immunogen
NS0-derived recombinant human CV-2 (aa34-685) Accession # NP_597725
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-BMPER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BMPER antibody
Crossveinless-2 (CV-2), also known as BMPER2 (BMP-binding endothelial regulator), is a secreted glycoprotein that contains a trypsin-inhibitory like domain, five cysteine-rich domains, and a von Willebrand factor type D domain. CV-2 modulates the activity of BMP-2 and BMP-4 in neural crest migration and osteoblast and chondrocyte differentiation. During zebrafish gastrulation, CV-2 is proteolytically cleaved to generate a BMP agonist from a BMP antagonist. Mature human and mouse CV-2 share 93% aa sequence identity.
Product Categories/Family for anti-BMPER antibody
Applications Tested/Suitable for anti-BMPER antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-BMPER antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-2ug/ml
NCBI/Uniprot data below describe general gene information for BMPER. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,997 Da[Similar Products]
NCBI Official Full Name
crossveinless-2
NCBI Official Synonym Full Names
BMP binding endothelial regulator
NCBI Official Symbol
BMPER  [Similar Products]
NCBI Official Synonym Symbols
CV2; CV-2; CRIM3; BMPER
  [Similar Products]
NCBI Protein Information
BMP-binding endothelial regulator protein; hCV2; crossveinless 2; crossveinless-2; OTTHUMP00000158859; protein crossveinless-2; BMP-binding endothelial regulator precursor protein; bone morphogenetic protein-binding endothelial cell precursor-derived regulator
UniProt Protein Name
BMP-binding endothelial regulator protein
UniProt Synonym Protein Names
Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2
UniProt Gene Name
BMPER  [Similar Products]
UniProt Synonym Gene Names
KIAA1965  [Similar Products]
UniProt Entry Name
BMPER_HUMAN
NCBI Summary for BMPER
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
UniProt Comments for BMPER
BMPER: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Defects in BMPER are the cause of diaphanospondylodysostosis (DSD). A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.

Protein type: Secreted, signal peptide; Inhibitor; Secreted

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: extracellular space

Biological Process: endothelial cell differentiation; blood vessel endothelial cell proliferation during sprouting angiogenesis; ureteric bud development; inner ear development; negative regulation of BMP signaling pathway; endothelial cell activation

Disease: Diaphanospondylodysostosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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