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anti-CRSP2 antibody :: Mouse anti-Human CRSP2 Monoclonal Antibody

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Catalog # MBS120156
Unit / Price
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  0.1 mg  /  $395 +1 FREE 8GB USB
Product Name

CRSP2, Monoclonal Antibody

Popular Item
Full Product Name

Mouse monoclonal antibody Anti-Human CRSP2

Product Synonym Names
Homo sapiens cofactor required for Sp1 transcriptional activation,subunit 2, 150kDa (CRSP2); CSRP; RGR1;EXLM1; MED14; CXorf4; CRSP150; DRIP150; TRAP170;MGC104513
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
300182
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2214C1a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Other Notes
Small volumes of anti-CRSP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRSP2 antibody
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [NCBI Entrez Gene Summary]
Applications Tested/Suitable for anti-CRSP2 antibody
Dot Blot (DB)

Quality Control of anti-CRSP2 antibody
Western blot analysis of immunized recombinant protein, using anti-CRSP2 monoclonal antibody.
anti-CRSP2 antibody Quality Control image
Quality Control #2 of anti-CRSP2 antibody
Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CRSP2 antibody Quality Control #2 image
NCBI/Uniprot data below describe general gene information for CRSP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,607 Da
NCBI Official Full Name
Homo sapiens mediator complex subunit 14 (MED14), mRNA
NCBI Official Synonym Full Names
mediator complex subunit 14
NCBI Official Symbol
MED14  [Similar Products]
NCBI Official Synonym Symbols
CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170
  [Similar Products]
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 14; ARC150; CRSP complex subunit 2; RGR1 homolog; activator-recruited cofactor 150 kDa component; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); hRGR1; human homolog of yeast RGR1; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; transcriptional co-activator CRSP150; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 14
UniProt Synonym Protein Names
Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150
UniProt Gene Name
MED14  [Similar Products]
UniProt Entry Name
MED14_HUMAN
NCBI Summary for CRSP2
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
UniProt Comments for CRSP2
Trap170: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; transcription cofactor activity; thyroid hormone receptor binding; receptor activity

Biological Process: steroid hormone receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; gene expression
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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